Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells

Mast cells possess specialized lysosomes, so-called secretory granules, which play a key role not only in allergic responses but also in various immune disorders. The molecular mechanisms that control secretory-granule formation are not fully understood. Solute carrier family member 15A4 (SLC15A4) i...

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Detalles Bibliográficos
Autores principales: Kobayashi, Toshihiko, Tsutsui, Hidemitsu, Shimabukuro-Demoto, Shiho, Yoshida-Sugitani, Reiko, Karyu, Hitomi, Furuyama-Tanaka, Kaori, Ohshima, Daisuke, Kato, Norihiro, Okamura, Tadashi, Toyama-Sorimachi, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890901/
https://www.ncbi.nlm.nih.gov/pubmed/29155995
http://dx.doi.org/10.1093/intimm/dxx063

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