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Evolving Artificial Metalloenzymes via Random Mutagenesis

Random mutagenesis has the potential to optimize the efficiency and selectivity of protein catalysts without requiring detailed knowledge of protein structure; however, introducing synthetic metal cofactors complicates the expression and screening of enzyme libraries, and activity arising from free...

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Detalles Bibliográficos
Autores principales:	Yang, Hao, Swartz, Alan M., Park, Hyun June, Srivastava, Poonam, Ellis-Guardiola, Ken, Upp, David M., Lee, Gihoon, Belsare, Ketaki, Gu, Yifan, Zhang, Chen, Moellering, Raymond E., Lewis, Jared C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891097/ https://www.ncbi.nlm.nih.gov/pubmed/29461523 http://dx.doi.org/10.1038/nchem.2927

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