Cargando…

SORCS1 and SORCS3 control energy balance and orexigenic peptide production

SORCS1 and SORCS3 are two related sorting receptors expressed in neurons of the arcuate nucleus of the hypothalamus. Using mouse models with individual or dual receptor deficiencies, we document a previously unknown function of these receptors in central control of metabolism. Specifically, SORCS1 a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subkhangulova, Aygul, Malik, Anna R, Hermey, Guido, Popp, Oliver, Dittmar, Gunnar, Rathjen, Thomas, Poy, Matthew N, Stumpf, Alexander, Beed, Prateep Sanker, Schmitz, Dietmar, Breiderhoff, Tilman, Willnow, Thomas E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891432/ https://www.ncbi.nlm.nih.gov/pubmed/29440124 http://dx.doi.org/10.15252/embr.201744810

Ejemplares similares

Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction
por: Breiderhoff, Tilman, et al.
Publicado: (2013)

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
por: Malik, Anna R., et al.
Publicado: (2019)

Impact of Genetic Variation in SORCS1 on Memory Retention
por: Reitz, Christiane, et al.
Publicado: (2011)

Overview of the Solar Radiation and Climate Experiment (SORCE) Seventeen-Year Mission
por: Woods, Thomas N., et al.
Publicado: (2021)

Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells
por: Yau, Belinda, et al.
Publicado: (2019)

The Solar Radiation and Climate Experiment (SORCE): Mission Description and Early Results
por: Rottman, G, et al.
Publicado: (2005)

Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
por: Gospodinova, Katerina O., et al.
Publicado: (2021)

Solar-Cycle Variability Results from the Solar Radiation and Climate Experiment (SORCE) Mission
por: Woods, Thomas N., et al.
Publicado: (2022)

Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
por: Boggild, Simon, et al.
Publicado: (2016)

Structural insights into SorCS2–Nerve Growth Factor complex formation
por: Leloup, Nadia, et al.
Publicado: (2018)

PM296. SORCS2 regulates alcohol withdrawal severity and excitatory synaptic transmission
por: Smith, Andrew H., et al.
Publicado: (2016)

SorCS3 promotes the internalization of p75(NTR) to inhibit GBM progression
por: Zhang, Yanqiu, et al.
Publicado: (2022)

Long-Term Trend Analysis in the Solar Radiation and Climate Experiment (SORCE)/Spectral Irradiance Monitor (SIM)
por: Harder, Jerald W., et al.
Publicado: (2022)

The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer’s Disease in Chinese Han Population
por: Xu, Wei, et al.
Publicado: (2013)

Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2
por: Olsen, Ditte, et al.
Publicado: (2019)

Sorting receptor SORLA: cellular mechanisms and implications for disease
por: Schmidt, Vanessa, et al.
Publicado: (2016)

Independent Associated SNPs at SORCS3 and Its Protein Interactors for Multiple Brain-Related Disorders and Traits
por: Kamran, Muhammad, et al.
Publicado: (2023)

SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function
por: Ribeiro, Luís F., et al.
Publicado: (2019)

SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology
por: Lee, Alfred Kihoon, et al.
Publicado: (2023)

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates
por: Nyborg, Andrew C, et al.
Publicado: (2006)

Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice
por: Olsen, Ditte, et al.
Publicado: (2021)

Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear
por: Forge, Andrew, et al.
Publicado: (2017)

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1
por: Knight, Elysse M., et al.
Publicado: (2016)

Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development
por: Skeldal, Sune, et al.
Publicado: (2023)

CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression
por: Xu, Junfen, et al.
Publicado: (2021)

External Validation of the 2003 Leibovich Prognostic Score in Patients Randomly Assigned to SORCE, an International Phase III Trial of Adjuvant Sorafenib in Renal Cell Cancer
por: Oza, Bhavna, et al.
Publicado: (2022)

GluK2-Mediated Excitability within the Superficial Layers of the Entorhinal Cortex
por: Beed, Prateep S., et al.
Publicado: (2009)

Correction: GluK2-Mediated Excitability within the Superficial Layers of the Entorhinal Cortex
por: Beed, Prateep S., et al.
Publicado: (2009)

What Survival Benefits are Needed to Make Adjuvant Sorafenib Worthwhile After Resection of Intermediate- or High-Risk Renal Cell Carcinoma? Clinical Investigators’ Preferences in the SORCE Trial
por: Lawrence, Nicola J., et al.
Publicado: (2018)

Science Highlights and Final Updates from 17 Years of Total Solar Irradiance Measurements from the SOlar Radiation and Climate Experiment/Total Irradiance Monitor (SORCE/TIM)
por: Kopp, Greg
Publicado: (2021)

LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer
por: Shkurnikov, Maxim, et al.
Publicado: (2019)

Somatostatin interneurons activated by 5-HT(2A) receptor suppress slow oscillations in medial entorhinal cortex
por: de Filippo, Roberto, et al.
Publicado: (2021)

Single neonatal dexamethasone administration has long-lasting outcome on depressive-like behaviour, Bdnf, Nt-3, p75ngfr and sorting receptors (SorCS1-3) stress reactive expression
por: Lanshakov, D. A., et al.
Publicado: (2021)

Early Cortical Changes in Gamma Oscillations in Alzheimer’s Disease
por: Klein, Alexandra S., et al.
Publicado: (2016)

VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons
por: Wozny, Christian, et al.
Publicado: (2018)

Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices
por: Tukker, John J., et al.
Publicado: (2020)

Species-specific differences in synaptic transmission and plasticity
por: Beed, Prateep, et al.
Publicado: (2020)

Striking a balance: Orexigenic and energy‐consuming effects of energy expenditure on body weight
por: Hopkins, Mark, et al.
Publicado: (2022)

Microcircuits for spatial coding in the medial entorhinal cortex
por: Tukker, John J., et al.
Publicado: (2022)

Parvalbumin Interneurons Are Differentially Connected to Principal Cells in Inhibitory Feedback Microcircuits along the Dorsoventral Axis of the Medial Entorhinal Cortex
por: Grosser, Sabine, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nqto5bd6sqdkivqaopuufbi2b0