Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion

Solitary bone plasmacytoma (SBP) tends to progress to multiple myeloma (MM); however, progression to multiple solitary plasmacytomas (MSP) is rare. We report a case of CD138-low MSP with 17p deletion in a patient with relapsed SBP. 17p deletion is associated with a poor outcome in patients with MM,...

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Autores principales: Kitamura, Hiroaki, Kubota, Yasushi, Yamaguchi, Kyosuke, Kamachi, Kazuharu, Nishioka, Atsujiro, Yokoo, Masako, Shindo, Takero, Ando, Toshihiko, Kojima, Kensuke, Kimura, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891527/
https://www.ncbi.nlm.nih.gov/pubmed/29151530
http://dx.doi.org/10.2169/internalmedicine.9446-17
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author Kitamura, Hiroaki
Kubota, Yasushi
Yamaguchi, Kyosuke
Kamachi, Kazuharu
Nishioka, Atsujiro
Yokoo, Masako
Shindo, Takero
Ando, Toshihiko
Kojima, Kensuke
Kimura, Shinya
author_facet Kitamura, Hiroaki
Kubota, Yasushi
Yamaguchi, Kyosuke
Kamachi, Kazuharu
Nishioka, Atsujiro
Yokoo, Masako
Shindo, Takero
Ando, Toshihiko
Kojima, Kensuke
Kimura, Shinya
author_sort Kitamura, Hiroaki
collection PubMed
description Solitary bone plasmacytoma (SBP) tends to progress to multiple myeloma (MM); however, progression to multiple solitary plasmacytomas (MSP) is rare. We report a case of CD138-low MSP with 17p deletion in a patient with relapsed SBP. 17p deletion is associated with a poor outcome in patients with MM, and the low expression of CD138 in myeloma cells is associated with drug resistance and a poor prognosis. The patient was successfully treated with bortezomib plus dexamethasone induction therapy and autologous hematopoietic stem cell transplantation followed by bortezomib maintenance therapy. Consequently, bortezomib treatment was stopped and a stringent complete response has been maintained.
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spelling pubmed-58915272018-04-12 Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion Kitamura, Hiroaki Kubota, Yasushi Yamaguchi, Kyosuke Kamachi, Kazuharu Nishioka, Atsujiro Yokoo, Masako Shindo, Takero Ando, Toshihiko Kojima, Kensuke Kimura, Shinya Intern Med Case Report Solitary bone plasmacytoma (SBP) tends to progress to multiple myeloma (MM); however, progression to multiple solitary plasmacytomas (MSP) is rare. We report a case of CD138-low MSP with 17p deletion in a patient with relapsed SBP. 17p deletion is associated with a poor outcome in patients with MM, and the low expression of CD138 in myeloma cells is associated with drug resistance and a poor prognosis. The patient was successfully treated with bortezomib plus dexamethasone induction therapy and autologous hematopoietic stem cell transplantation followed by bortezomib maintenance therapy. Consequently, bortezomib treatment was stopped and a stringent complete response has been maintained. The Japanese Society of Internal Medicine 2017-11-20 2018-03-15 /pmc/articles/PMC5891527/ /pubmed/29151530 http://dx.doi.org/10.2169/internalmedicine.9446-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kitamura, Hiroaki
Kubota, Yasushi
Yamaguchi, Kyosuke
Kamachi, Kazuharu
Nishioka, Atsujiro
Yokoo, Masako
Shindo, Takero
Ando, Toshihiko
Kojima, Kensuke
Kimura, Shinya
Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title_full Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title_fullStr Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title_full_unstemmed Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title_short Successful Autologous Hematopoietic Stem Cell Transplantation Followed by Bortezomib Maintenance in a Patient with Relapsed CD138-low Multiple Solitary Plasmacytomas Harboring a 17p Deletion
title_sort successful autologous hematopoietic stem cell transplantation followed by bortezomib maintenance in a patient with relapsed cd138-low multiple solitary plasmacytomas harboring a 17p deletion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891527/
https://www.ncbi.nlm.nih.gov/pubmed/29151530
http://dx.doi.org/10.2169/internalmedicine.9446-17
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