Expansion of NKG2C-expressing Natural Killer Cells after Umbilical Cord Blood Transplantation in a Patient with Peripheral T-cell Lymphoma with Cytotoxic Molecules

A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial...

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Detalles Bibliográficos
Autores principales: Muta, Tsuyoshi, Yoshihiro, Tomoyasu, Jinnouchi, Fumiaki, Aoki, Kenichi, Kochi, Yu, Shima, Takahiro, Takenaka, Katsuto, Ogawa, Ryosuke, Akashi, Koichi, Oshima, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891528/
https://www.ncbi.nlm.nih.gov/pubmed/29269653
http://dx.doi.org/10.2169/internalmedicine.9437-17
Descripción
Sumario:A 64-year-old woman presented with generalized lymphadenopathy and systemic manifestations. The examination of a biopsy specimen revealed peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) expressing cytotoxic molecules. Umbilical cord blood transplantation was successful during a partial remission state after the administration of salvage chemotherapy. The donor-derived large granular lymphocytes started to increase as a result of cytomegalovirus reactivation. The fraction of natural killer (NK) cells expressing the NKG2C molecule accounted for one-third of the total lymphocytes for almost two years. We implicitly indicate the association between the persistence of donor-derived NKG2C(+) NK cell-expansion and maintaining a complete remission in similar cases of aggressive PTCL-NOS.

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