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The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to descr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891591/ https://www.ncbi.nlm.nih.gov/pubmed/29666604 http://dx.doi.org/10.3389/fendo.2018.00121 |
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author | Baldini, Chiara Ferro, Francesco Mosca, Marta Fallahi, Poupak Antonelli, Alessandro |
author_facet | Baldini, Chiara Ferro, Francesco Mosca, Marta Fallahi, Poupak Antonelli, Alessandro |
author_sort | Baldini, Chiara |
collection | PubMed |
description | Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS–AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa. Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD–SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD–SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions. |
format | Online Article Text |
id | pubmed-5891591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58915912018-04-17 The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders Baldini, Chiara Ferro, Francesco Mosca, Marta Fallahi, Poupak Antonelli, Alessandro Front Endocrinol (Lausanne) Endocrinology Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS–AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa. Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD–SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD–SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions. Frontiers Media S.A. 2018-04-03 /pmc/articles/PMC5891591/ /pubmed/29666604 http://dx.doi.org/10.3389/fendo.2018.00121 Text en Copyright © 2018 Baldini, Ferro, Mosca, Fallahi and Antonelli. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Baldini, Chiara Ferro, Francesco Mosca, Marta Fallahi, Poupak Antonelli, Alessandro The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title | The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title_full | The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title_fullStr | The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title_full_unstemmed | The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title_short | The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders |
title_sort | association of sjögren syndrome and autoimmune thyroid disorders |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891591/ https://www.ncbi.nlm.nih.gov/pubmed/29666604 http://dx.doi.org/10.3389/fendo.2018.00121 |
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