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The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders

Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to descr...

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Autores principales: Baldini, Chiara, Ferro, Francesco, Mosca, Marta, Fallahi, Poupak, Antonelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891591/
https://www.ncbi.nlm.nih.gov/pubmed/29666604
http://dx.doi.org/10.3389/fendo.2018.00121
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author Baldini, Chiara
Ferro, Francesco
Mosca, Marta
Fallahi, Poupak
Antonelli, Alessandro
author_facet Baldini, Chiara
Ferro, Francesco
Mosca, Marta
Fallahi, Poupak
Antonelli, Alessandro
author_sort Baldini, Chiara
collection PubMed
description Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS–AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa. Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD–SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD–SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions.
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spelling pubmed-58915912018-04-17 The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders Baldini, Chiara Ferro, Francesco Mosca, Marta Fallahi, Poupak Antonelli, Alessandro Front Endocrinol (Lausanne) Endocrinology Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS–AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa. Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD–SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD–SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions. Frontiers Media S.A. 2018-04-03 /pmc/articles/PMC5891591/ /pubmed/29666604 http://dx.doi.org/10.3389/fendo.2018.00121 Text en Copyright © 2018 Baldini, Ferro, Mosca, Fallahi and Antonelli. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Baldini, Chiara
Ferro, Francesco
Mosca, Marta
Fallahi, Poupak
Antonelli, Alessandro
The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title_full The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title_fullStr The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title_full_unstemmed The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title_short The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders
title_sort association of sjögren syndrome and autoimmune thyroid disorders
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891591/
https://www.ncbi.nlm.nih.gov/pubmed/29666604
http://dx.doi.org/10.3389/fendo.2018.00121
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