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Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation

In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory prop...

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Detalles Bibliográficos
Autores principales:	Li, Chuwen, Zhang, Chao, Zhou, Hefeng, Feng, Yu, Tang, Fan, Hoi, Maggie P. M., He, Chengwei, Ma, Dan, Zhao, Chao, Lee, Simon M. Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891622/ https://www.ncbi.nlm.nih.gov/pubmed/29666569 http://dx.doi.org/10.3389/fnmol.2018.00098

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