Cover Feature: Macromolecular Crowding May Significantly Affect the Performance of an MRI Contrast Agent: A (1)H NMR Spectroscopy, Microimaging, and Fast‐Field‐Cycling NMR Relaxometry Study (ChemistryOpen 4/2018)

The Cover Feature shows that macromolecular crowders PEG or BSA in an aqueous solution of a paramagnetic magnetic resonance imaging (MRI) contrast agent generally bring additional proton spin relaxation to the water molecules close to the paramagnetic ion and lead to contrast change in the MRI image...

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Detalles Bibliográficos
Autores principales: Cheng, Ren‐Hao, Chen, Jie‐Min, Chen, Yu‐Wen, Cai, Honghao, Cui, Xiaohong, Hwang, Dennis W., Chen, Zhong, Ding, Shangwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891658/
http://dx.doi.org/10.1002/open.201800033
Descripción
Sumario:The Cover Feature shows that macromolecular crowders PEG or BSA in an aqueous solution of a paramagnetic magnetic resonance imaging (MRI) contrast agent generally bring additional proton spin relaxation to the water molecules close to the paramagnetic ion and lead to contrast change in the MRI images. This highlights the importance of considering the effect of macromolecular crowding on the performance of MRI contrast agents and image analysis, as well as diagnosis in clinical and functional MRI. More information can be found in the Full Paper on page 288 in Issue 4, 2018 by R.‐H. Cheng et al. (DOI: https://doi.org/10.1002/open.201700192).[Image: see text]

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