The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene

AIM: The aim of this study was to analyze the effect of moderate exercise on the elevation of Bax/Bcl-2 ratio. MATERIALS AND METHODS: Eighteen Mus musculus strain Swiss Webster (Balb/c) were divided into three groups (n=6). K1 and K2 had contact with water 3 times/week for 12 weeks, while the member...

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Detalles Bibliográficos
Autores principales: Irmawati, Anis, Jasmin, Nadira, Sidarningsih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891871/
https://www.ncbi.nlm.nih.gov/pubmed/29657400
http://dx.doi.org/10.14202/vetworld.2018.177-180
Descripción
Sumario:AIM: The aim of this study was to analyze the effect of moderate exercise on the elevation of Bax/Bcl-2 ratio. MATERIALS AND METHODS: Eighteen Mus musculus strain Swiss Webster (Balb/c) were divided into three groups (n=6). K1 and K2 had contact with water 3 times/week for 12 weeks, while the members of the K3 group swam 3 times/week for 12 weeks while carrying load weighed 3% of their body weight. After 5 weeks, they were induced with 0.04 ml oleum olivarum (K1), 0.08 mg benzopyrene/0.04 ml oleum olivarum (K2, K3) 3 times/week for 4 weeks. Immunohistochemistry assays were used to determine the ratio of Bax/Bcl-2 expression. The results were analyzed using an independent t-test. RESULT: The Bax/Bcl-2 ratio increased significantly in K3 compared to K2 (p=0.00). CONCLUSION: Moderate exercise could increase the Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene.

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