Cargando…

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications

The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote tumorigenesis, EBV must restrict its lytic cycle, which would ultimately lead to cell deat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giunco, Silvia, Petrara, Maria Raffaella, Zangrossi, Manuela, Celeghin, Andrea, De Rossi, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892012/ https://www.ncbi.nlm.nih.gov/pubmed/29643934 http://dx.doi.org/10.1186/s13027-018-0186-5

Ejemplares similares

Epstein-Barr virus and telomerase: from cell immortalization to therapy
por: Dolcetti, Riccardo, et al.
Publicado: (2014)

Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish
por: Giunco, Silvia, et al.
Publicado: (2020)

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells
por: Celeghin, Andrea, et al.
Publicado: (2016)

Epstein-Barr virus-driven lymphomagenesis in the context of human immunodeficiency virus type 1 infection
por: Petrara, Maria R., et al.
Publicado: (2013)

Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications
por: Boscolo-Rizzo, Paolo, et al.
Publicado: (2016)

Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach
por: Amin, Aamir, et al.
Publicado: (2023)

Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus
por: Petrara, Maria Raffaella, et al.
Publicado: (2017)

Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus
por: Giunco, S, et al.
Publicado: (2015)

Relationship between Non-Hodgkin’s lymphoma and blood levels of Epstein-Barr Virus in children in north-western Tanzania: a case control study
por: Kabyemera, Rogatus, et al.
Publicado: (2013)

Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models
por: Sung, Young Hoon, et al.
Publicado: (2014)

Telomerase Activity Impacts on Epstein-Barr Virus Infection of AGS Cells
por: Rac, Jürgen, et al.
Publicado: (2015)

Epstein–Barr Virus History and Pathogenesis
por: Yu, Hui, et al.
Publicado: (2023)

Predictive and prognostic significance of telomerase levels/telomere length in tissues and peripheral blood in head and neck squamous cell carcinoma
por: Boscolo-Rizzo, Paolo, et al.
Publicado: (2019)

Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein–Barr virus
por: Kamranvar, S A, et al.
Publicado: (2013)

Regulation of Telomere Homeostasis during Epstein-Barr virus Infection and Immortalization
por: Kamranvar, Siamak A., et al.
Publicado: (2017)

Canonical and extra‐telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training
por: Denham, Joshua
Publicado: (2023)

Relationship between dynamics of Epstein-Barr virus and immune activation in HIV-1 infected subjects in the HAART era
por: Cattelan, AM, et al.
Publicado: (2010)

Telomeres and Telomerase: Role in Marek’s Disease Virus Pathogenesis, Integration and Tumorigenesis
por: Kheimar, Ahmed, et al.
Publicado: (2017)

Telomeres and telomerase in oncogenesis
por: Trybek, Tomasz, et al.
Publicado: (2020)

The role of Epstein–Barr virus in epithelial malignancies
por: Tsao, Sai-Wah, et al.
Publicado: (2015)

The Microenvironment in Epstein–Barr Virus-Associated Malignancies
por: Tan, Geok Wee, et al.
Publicado: (2018)

Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse
por: Remes, K, et al.
Publicado: (2000)

Immune senescence and immune activation in elderly colorectal cancer patients
por: Giunco, Silvia, et al.
Publicado: (2019)

The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis
por: Pender, Michael P.
Publicado: (2011)

Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice
por: Fujiwara, Shigeyoshi
Publicado: (2014)

Extracellular Vesicles in Epstein-Barr Virus’ Life Cycle and Pathogenesis
por: Zhao, Mengmeng, et al.
Publicado: (2019)

Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies
por: Xu, Miao, et al.
Publicado: (2019)

157 Pathogenesis of Epstein-Barr Virus-driven lymphomas of HIV+ patients: new insights of potential clinical relevance
por: Dolcetti, Riccardo
Publicado: (2014)

The role of telomeres and telomerase in hematologic malignancies and hematopoietic stem cell transplantation
por: Wang, Limengmeng, et al.
Publicado: (2014)

Molecular Genetics in Epstein–Barr Virus-Associated Malignancies
por: Umakanthan, Srikanth, et al.
Publicado: (2021)

Telomere and telomerase in stem cells
por: Hiyama, E, et al.
Publicado: (2007)

Telomeres and Telomerase in Cardiovascular Diseases
por: Yeh, Jih-Kai, et al.
Publicado: (2016)

Telomere and Telomerase Therapeutics in Cancer
por: Xu, Yucheng, et al.
Publicado: (2016)

Telomerase and Telomeres in Endometrial Cancer
por: Alnafakh, Rafah A. A., et al.
Publicado: (2019)

Mitochondria, Telomeres and Telomerase Subunits
por: Zheng, Qian, et al.
Publicado: (2019)

How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis
por: Tomita, Kazunori
Publicado: (2018)

Epstein-Barr Virus MicroRNA Expression Increases Aggressiveness of Solid Malignancies
por: Pandya, Deep, et al.
Publicado: (2015)

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
por: Jafri, Mohammad A., et al.
Publicado: (2016)

Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations
por: Fox, Christopher P, et al.
Publicado: (2011)

Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis
por: Iwakiri, Dai
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_bvl6pik145ku28n9n3gii0c47r