Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

BACKGROUND: Cytarabine arabinoside (Ara-C) has been the core of chemotherapy for adult acute myeloid leukemia (AML). Ara-C undergoes a three-step phosphorylation into the active metabolite Ara-C triphosphosphate (ara-CTP). Several enzymes are involved directly or indirectly in either the formation o...

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Detalles Bibliográficos
Autores principales: Zhu, Ke-Wei, Chen, Peng, Zhang, Dao-Yu, Yan, Han, Liu, Han, Cen, Li-Na, Liu, Yan-Ling, Cao, Shan, Zhou, Gan, Zeng, Hui, Chen, Shu-Ping, Zhao, Xie-Lan, Chen, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892020/
https://www.ncbi.nlm.nih.gov/pubmed/29631596
http://dx.doi.org/10.1186/s12967-018-1463-1

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