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Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides
Intramolecular N-to-S or N-to-O acyl shifts in peptides are of fundamental and practical importance, as they constitute the first step in protein splicing and can be used for the synthesis of thioester-modified peptides required for native chemical ligation. It has been stated that the nucleophile m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Royal Society of Chemistry
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892126/ https://www.ncbi.nlm.nih.gov/pubmed/29675223 http://dx.doi.org/10.1039/c7sc04046f |