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Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations

Peptidyl thioesters or their surrogates with C-terminal β-branched hydrophobic amino acid residues usually exhibit poor reactivities in ligation reactions. Thus, activation using exogenous additives is required to ensure an acceptable reaction efficiency. Herein, we report a traceless ligation at Va...

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Detalles Bibliográficos
Autores principales: Wang, Yinglu, Han, Lin, Yuan, Ning, Wang, Hanxuan, Li, Hongxing, Liu, Jinrong, Chen, Huan, Zhang, Qiang, Dong, Suwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892131/
https://www.ncbi.nlm.nih.gov/pubmed/29675240
http://dx.doi.org/10.1039/c7sc04148a

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