Cargando…
Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study
Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress co...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892211/ https://www.ncbi.nlm.nih.gov/pubmed/29780571 http://dx.doi.org/10.1155/2018/3751516 |
_version_ | 1783313128506785792 |
---|---|
author | Waldner, Andreas Dassati, Sarah Redl, Bernhard Smania, Nicola Gandolfi, Marialuisa |
author_facet | Waldner, Andreas Dassati, Sarah Redl, Bernhard Smania, Nicola Gandolfi, Marialuisa |
author_sort | Waldner, Andreas |
collection | PubMed |
description | Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system. Preliminary findings support the role of ApoD in neuroprotection. However, its role in PD remains unclear. To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage. We investigated the concentration of ApoD in the blood of healthy control subjects and PD patients with mild-to-moderate neurological impairment. ApoD plasma levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA) in 90 healthy subjects (aging-analysis cohort) and in 66 PD patients at different stages compared with 19 age-matched healthy subjects. Significant age-related increase of ApoD was detected in subjects older than 65 years of age (p < 0.002). In PD patients, a significant increase in ApoD plasma concentration was found compared with healthy subjects of the same age (p < 0.05). ApoD and PD stage are significantly correlated (p < 0.05). ApoD might be a valid marker for the progression of PD. |
format | Online Article Text |
id | pubmed-5892211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58922112018-05-20 Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study Waldner, Andreas Dassati, Sarah Redl, Bernhard Smania, Nicola Gandolfi, Marialuisa Parkinsons Dis Research Article Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system. Preliminary findings support the role of ApoD in neuroprotection. However, its role in PD remains unclear. To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage. We investigated the concentration of ApoD in the blood of healthy control subjects and PD patients with mild-to-moderate neurological impairment. ApoD plasma levels were measured using sandwich enzyme-linked immunosorbent assays (ELISA) in 90 healthy subjects (aging-analysis cohort) and in 66 PD patients at different stages compared with 19 age-matched healthy subjects. Significant age-related increase of ApoD was detected in subjects older than 65 years of age (p < 0.002). In PD patients, a significant increase in ApoD plasma concentration was found compared with healthy subjects of the same age (p < 0.05). ApoD and PD stage are significantly correlated (p < 0.05). ApoD might be a valid marker for the progression of PD. Hindawi 2018-03-26 /pmc/articles/PMC5892211/ /pubmed/29780571 http://dx.doi.org/10.1155/2018/3751516 Text en Copyright © 2018 Andreas Waldner et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Waldner, Andreas Dassati, Sarah Redl, Bernhard Smania, Nicola Gandolfi, Marialuisa Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title | Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title_full | Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title_fullStr | Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title_full_unstemmed | Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title_short | Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson's Disease: A Cross-Sectional Study |
title_sort | apolipoprotein d concentration in human plasma during aging and in parkinson's disease: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892211/ https://www.ncbi.nlm.nih.gov/pubmed/29780571 http://dx.doi.org/10.1155/2018/3751516 |
work_keys_str_mv | AT waldnerandreas apolipoproteindconcentrationinhumanplasmaduringagingandinparkinsonsdiseaseacrosssectionalstudy AT dassatisarah apolipoproteindconcentrationinhumanplasmaduringagingandinparkinsonsdiseaseacrosssectionalstudy AT redlbernhard apolipoproteindconcentrationinhumanplasmaduringagingandinparkinsonsdiseaseacrosssectionalstudy AT smanianicola apolipoproteindconcentrationinhumanplasmaduringagingandinparkinsonsdiseaseacrosssectionalstudy AT gandolfimarialuisa apolipoproteindconcentrationinhumanplasmaduringagingandinparkinsonsdiseaseacrosssectionalstudy |