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The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD(+), whi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892213/ https://www.ncbi.nlm.nih.gov/pubmed/29769837 http://dx.doi.org/10.1155/2018/7019398 |
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author | Morandi, F. Horenstein, A. L. Rizzo, R. Malavasi, F. |
author_facet | Morandi, F. Horenstein, A. L. Rizzo, R. Malavasi, F. |
author_sort | Morandi, F. |
collection | PubMed |
description | Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD(+), which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models. The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases. |
format | Online Article Text |
id | pubmed-5892213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58922132018-05-16 The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases Morandi, F. Horenstein, A. L. Rizzo, R. Malavasi, F. Mediators Inflamm Review Article Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD(+), which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models. The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases. Hindawi 2018-03-26 /pmc/articles/PMC5892213/ /pubmed/29769837 http://dx.doi.org/10.1155/2018/7019398 Text en Copyright © 2018 F. Morandi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Morandi, F. Horenstein, A. L. Rizzo, R. Malavasi, F. The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title_full | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title_fullStr | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title_full_unstemmed | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title_short | The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases |
title_sort | role of extracellular adenosine generation in the development of autoimmune diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892213/ https://www.ncbi.nlm.nih.gov/pubmed/29769837 http://dx.doi.org/10.1155/2018/7019398 |
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