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Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome

Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like pres...

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Detalles Bibliográficos
Autores principales: Abugroun, Ashraf, Chaudhary, Ahmed, Rodriguez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892290/
https://www.ncbi.nlm.nih.gov/pubmed/29780651
http://dx.doi.org/10.1155/2018/6291614
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author Abugroun, Ashraf
Chaudhary, Ahmed
Rodriguez, Gabriel
author_facet Abugroun, Ashraf
Chaudhary, Ahmed
Rodriguez, Gabriel
author_sort Abugroun, Ashraf
collection PubMed
description Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature. To the best of our knowledge, so far, no previous case of cytokine storm associated with imatinib has been reported. We herein present a case report of a 77-year-old male with a past medical history of hypereosinophilic syndrome who developed acute fatal cytokine storm following treatment with imatinib. This study highlights a life-threatening complication of the medication that may be underrecognized.
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spelling pubmed-58922902018-05-20 Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome Abugroun, Ashraf Chaudhary, Ahmed Rodriguez, Gabriel Case Rep Oncol Med Case Report Cytokine storm is a poorly explained clinical entity caused by an undesired and aggrandized immune system response leading to unregulated activation of the proinflammatory cascade, often contributing to multisystem organ failure and even death. Its potentially diverse etiologies and sepsis-like presentation have made it even more challenging to diagnose, and so far, no well-established treatment protocol has been proposed. Its association with certain medications, especially with monoclonal antibodies, has well been reported in literature. To the best of our knowledge, so far, no previous case of cytokine storm associated with imatinib has been reported. We herein present a case report of a 77-year-old male with a past medical history of hypereosinophilic syndrome who developed acute fatal cytokine storm following treatment with imatinib. This study highlights a life-threatening complication of the medication that may be underrecognized. Hindawi 2018-03-26 /pmc/articles/PMC5892290/ /pubmed/29780651 http://dx.doi.org/10.1155/2018/6291614 Text en Copyright © 2018 Ashraf Abugroun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Abugroun, Ashraf
Chaudhary, Ahmed
Rodriguez, Gabriel
Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title_full Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title_fullStr Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title_full_unstemmed Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title_short Fatal Outcome of Imatinib in a Patient with Idiopathic Hypereosinophilic Syndrome
title_sort fatal outcome of imatinib in a patient with idiopathic hypereosinophilic syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892290/
https://www.ncbi.nlm.nih.gov/pubmed/29780651
http://dx.doi.org/10.1155/2018/6291614
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