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New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates

Phthalocyanine (Pc) molecules exhibit high extinction coefficients in near-infrared region, rendering them well-suited for phototherapies, but most of their applications are limited to the field of photodynamic therapy (PDT). Herein, for the first time, we illustrate that Pc molecules can be endowed...

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Autores principales: Li, Xingshu, Peng, Xiao-Hui, Zheng, Bing-De, Tang, Jilin, Zhao, Yuanyuan, Zheng, Bi-Yuan, Ke, Mei-Rong, Huang, Jian-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892404/
https://www.ncbi.nlm.nih.gov/pubmed/29675251
http://dx.doi.org/10.1039/c7sc05115h
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author Li, Xingshu
Peng, Xiao-Hui
Zheng, Bing-De
Tang, Jilin
Zhao, Yuanyuan
Zheng, Bi-Yuan
Ke, Mei-Rong
Huang, Jian-Dong
author_facet Li, Xingshu
Peng, Xiao-Hui
Zheng, Bing-De
Tang, Jilin
Zhao, Yuanyuan
Zheng, Bi-Yuan
Ke, Mei-Rong
Huang, Jian-Dong
author_sort Li, Xingshu
collection PubMed
description Phthalocyanine (Pc) molecules exhibit high extinction coefficients in near-infrared region, rendering them well-suited for phototherapies, but most of their applications are limited to the field of photodynamic therapy (PDT). Herein, for the first time, we illustrate that Pc molecules can be endowed with excellent photothermal properties by means of structural regulation rather than formation of aggregates. Three representative Pc derivatives show efficient activities of photothermal therapy (PTT) against human hepatocellular carcinoma cells. Among them, copper phthalocyanine (PcC1) exhibits a high in vivo PTT efficacy against mice bearing S180 tumors. The unique investigation in this article should light up a perspective of Pc's new applications for PTT, which enable to make up the inherent defects of PDT.
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spelling pubmed-58924042018-04-19 New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates Li, Xingshu Peng, Xiao-Hui Zheng, Bing-De Tang, Jilin Zhao, Yuanyuan Zheng, Bi-Yuan Ke, Mei-Rong Huang, Jian-Dong Chem Sci Chemistry Phthalocyanine (Pc) molecules exhibit high extinction coefficients in near-infrared region, rendering them well-suited for phototherapies, but most of their applications are limited to the field of photodynamic therapy (PDT). Herein, for the first time, we illustrate that Pc molecules can be endowed with excellent photothermal properties by means of structural regulation rather than formation of aggregates. Three representative Pc derivatives show efficient activities of photothermal therapy (PTT) against human hepatocellular carcinoma cells. Among them, copper phthalocyanine (PcC1) exhibits a high in vivo PTT efficacy against mice bearing S180 tumors. The unique investigation in this article should light up a perspective of Pc's new applications for PTT, which enable to make up the inherent defects of PDT. Royal Society of Chemistry 2018-01-08 /pmc/articles/PMC5892404/ /pubmed/29675251 http://dx.doi.org/10.1039/c7sc05115h Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Li, Xingshu
Peng, Xiao-Hui
Zheng, Bing-De
Tang, Jilin
Zhao, Yuanyuan
Zheng, Bi-Yuan
Ke, Mei-Rong
Huang, Jian-Dong
New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title_full New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title_fullStr New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title_full_unstemmed New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title_short New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
title_sort new application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892404/
https://www.ncbi.nlm.nih.gov/pubmed/29675251
http://dx.doi.org/10.1039/c7sc05115h
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