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Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children

Neuroblastoma is the third most common childhood cancer after leukemias and cancer of the central nervous system. Long noncoding RNA MEG3 polymorphisms have been shown to confer cancer susceptibility; however, their roles in the genetic predisposition to neuroblastoma remain unclarified. To answer t...

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Autores principales: Zhuo, Zhen-Jian, Zhang, Ruizhong, Zhang, Jiao, Zhu, Jinhong, Yang, Tianyou, Zou, Yan, He, Jing, Xia, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892699/
https://www.ncbi.nlm.nih.gov/pubmed/29615542
http://dx.doi.org/10.18632/aging.101406
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author Zhuo, Zhen-Jian
Zhang, Ruizhong
Zhang, Jiao
Zhu, Jinhong
Yang, Tianyou
Zou, Yan
He, Jing
Xia, Huimin
author_facet Zhuo, Zhen-Jian
Zhang, Ruizhong
Zhang, Jiao
Zhu, Jinhong
Yang, Tianyou
Zou, Yan
He, Jing
Xia, Huimin
author_sort Zhuo, Zhen-Jian
collection PubMed
description Neuroblastoma is the third most common childhood cancer after leukemias and cancer of the central nervous system. Long noncoding RNA MEG3 polymorphisms have been shown to confer cancer susceptibility; however, their roles in the genetic predisposition to neuroblastoma remain unclarified. To answer this question, we genotyped two MEG3 polymorphisms, rs7158663 G>A and rs4081134 G>A, in 392 neuroblastoma children and 783 controls by TaqMan method. The results showed that neither single locus nor the combination analysis supported an association between MEG3 polymorphism and neuroblastoma risk. Interestingly, we found that subjects carrying rs4081134 AG/AA genotypes significantly tended to develop neuroblastoma among subgroups with age >18 month (adjusted OR=1.36, 95% CI=1.01-1.84) and clinical stage III+IV disease (adjusted OR=1.47, 95% CI=1.08-1.99), when compared with reference group. In the combined analysis of MEG3 polymorphisms, we found that carriers of 2 risk genotypes were more likely to have higher risk of developing neuroblastoma than those with 0-1 risk genotype among children more than 18 months of age (adjusted OR=1.36, 95% CI=1.01-1.84, P=0.042), and with clinical stages III+IV disease (adjusted OR=1.47, 95% CI=1.08-2.00, P=0.014). Our data suggest MEG3 as a weak-effect neuroblastoma susceptibility gene. Well-designed studies with large sample studies are needed to further validate this finding.
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spelling pubmed-58926992018-04-13 Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children Zhuo, Zhen-Jian Zhang, Ruizhong Zhang, Jiao Zhu, Jinhong Yang, Tianyou Zou, Yan He, Jing Xia, Huimin Aging (Albany NY) Research Paper Neuroblastoma is the third most common childhood cancer after leukemias and cancer of the central nervous system. Long noncoding RNA MEG3 polymorphisms have been shown to confer cancer susceptibility; however, their roles in the genetic predisposition to neuroblastoma remain unclarified. To answer this question, we genotyped two MEG3 polymorphisms, rs7158663 G>A and rs4081134 G>A, in 392 neuroblastoma children and 783 controls by TaqMan method. The results showed that neither single locus nor the combination analysis supported an association between MEG3 polymorphism and neuroblastoma risk. Interestingly, we found that subjects carrying rs4081134 AG/AA genotypes significantly tended to develop neuroblastoma among subgroups with age >18 month (adjusted OR=1.36, 95% CI=1.01-1.84) and clinical stage III+IV disease (adjusted OR=1.47, 95% CI=1.08-1.99), when compared with reference group. In the combined analysis of MEG3 polymorphisms, we found that carriers of 2 risk genotypes were more likely to have higher risk of developing neuroblastoma than those with 0-1 risk genotype among children more than 18 months of age (adjusted OR=1.36, 95% CI=1.01-1.84, P=0.042), and with clinical stages III+IV disease (adjusted OR=1.47, 95% CI=1.08-2.00, P=0.014). Our data suggest MEG3 as a weak-effect neuroblastoma susceptibility gene. Well-designed studies with large sample studies are needed to further validate this finding. Impact Journals 2018-03-27 /pmc/articles/PMC5892699/ /pubmed/29615542 http://dx.doi.org/10.18632/aging.101406 Text en Copyright © 2018 Zhou et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Zhuo, Zhen-Jian
Zhang, Ruizhong
Zhang, Jiao
Zhu, Jinhong
Yang, Tianyou
Zou, Yan
He, Jing
Xia, Huimin
Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title_full Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title_fullStr Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title_full_unstemmed Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title_short Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children
title_sort associations between lncrna meg3 polymorphisms and neuroblastoma risk in chinese children
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892699/
https://www.ncbi.nlm.nih.gov/pubmed/29615542
http://dx.doi.org/10.18632/aging.101406
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