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Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms underlying cancer immunotherapy. To this end, nonobese diabetic (NOD).Cg-Prkdc(scid)IL2rg(tm1Wjl)/Sz (null; NSG) mice were transplanted with h...

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Detalles Bibliográficos
Autores principales:	Wang, Minan, Yao, Li-Chin, Cheng, Mingshan, Cai, Danying, Martinek, Jan, Pan, Chong-Xian, Shi, Wei, Ma, Ai-Hong, De Vere White, Ralph W., Airhart, Susan, Liu, Edison T., Banchereau, Jacques, Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Palucka, Karolina, Keck, James G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892726/ https://www.ncbi.nlm.nih.gov/pubmed/29146734 http://dx.doi.org/10.1096/fj.201700740R

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