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Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications
The aim of this study is to disclose the potential bioactive components of Cuscuta palaestina, a native parasitic natural plant of flora palaestina and to open direction towards new prospective application. GC-MS analysis identified 18 components in the methanolic extract of C. palaestina for the fi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892908/ https://www.ncbi.nlm.nih.gov/pubmed/29634770 http://dx.doi.org/10.1371/journal.pone.0195707 |
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author | Abu-Lafi, Saleh Makhamra, Sadam Rayan, Ibrahim Barriah, Waseim Nasser, Ahmed Abu Farkh, Basheer Rayan, Anwar |
author_facet | Abu-Lafi, Saleh Makhamra, Sadam Rayan, Ibrahim Barriah, Waseim Nasser, Ahmed Abu Farkh, Basheer Rayan, Anwar |
author_sort | Abu-Lafi, Saleh |
collection | PubMed |
description | The aim of this study is to disclose the potential bioactive components of Cuscuta palaestina, a native parasitic natural plant of flora palaestina and to open direction towards new prospective application. GC-MS analysis identified 18 components in the methanolic extract of C. palaestina for the first time. The most appealing among them are Sesamin and two other phytosterols (Campesterol and Stigmasterol), all of which are documented in the scientific literature for their anticancer activity. Quantitation of Sesamin extracted from C. palaestina by HPLC-PDA with the use of three organic solvents showed that the Sesamin content in the methanolic extract was the highest. Following the disclosure of Sesamin presence in C. palaestina, we raised the question of whether it is produced naturally in C. palaestina or acquired from the host plant. The quantitation of Sesamin in C. palaestina was performed while being with five different host plants, and was compared with the amount of Sesamin in C. palaestina grown alone. The findings reveal that Sesamin is an endogenous secondary metabolite in C. palaestina. Thus, further studies are required to prove if C. palaestina can be used as an alternative source of anticancer phytochemicals, mainly Sesamin, and if proteins in the Sesamin production pathway could be valid biological targets for the development of novel and selective pesticides for control/ eradication of C. palaestina and maybe some other Cuscuta species. As well, the findings from this study raise a big question of whether inferring Sesamin production in C. palaestina could reduce its attack ability to host plants. |
format | Online Article Text |
id | pubmed-5892908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58929082018-04-20 Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications Abu-Lafi, Saleh Makhamra, Sadam Rayan, Ibrahim Barriah, Waseim Nasser, Ahmed Abu Farkh, Basheer Rayan, Anwar PLoS One Research Article The aim of this study is to disclose the potential bioactive components of Cuscuta palaestina, a native parasitic natural plant of flora palaestina and to open direction towards new prospective application. GC-MS analysis identified 18 components in the methanolic extract of C. palaestina for the first time. The most appealing among them are Sesamin and two other phytosterols (Campesterol and Stigmasterol), all of which are documented in the scientific literature for their anticancer activity. Quantitation of Sesamin extracted from C. palaestina by HPLC-PDA with the use of three organic solvents showed that the Sesamin content in the methanolic extract was the highest. Following the disclosure of Sesamin presence in C. palaestina, we raised the question of whether it is produced naturally in C. palaestina or acquired from the host plant. The quantitation of Sesamin in C. palaestina was performed while being with five different host plants, and was compared with the amount of Sesamin in C. palaestina grown alone. The findings reveal that Sesamin is an endogenous secondary metabolite in C. palaestina. Thus, further studies are required to prove if C. palaestina can be used as an alternative source of anticancer phytochemicals, mainly Sesamin, and if proteins in the Sesamin production pathway could be valid biological targets for the development of novel and selective pesticides for control/ eradication of C. palaestina and maybe some other Cuscuta species. As well, the findings from this study raise a big question of whether inferring Sesamin production in C. palaestina could reduce its attack ability to host plants. Public Library of Science 2018-04-10 /pmc/articles/PMC5892908/ /pubmed/29634770 http://dx.doi.org/10.1371/journal.pone.0195707 Text en © 2018 Abu-Lafi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Abu-Lafi, Saleh Makhamra, Sadam Rayan, Ibrahim Barriah, Waseim Nasser, Ahmed Abu Farkh, Basheer Rayan, Anwar Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title | Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title_full | Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title_fullStr | Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title_full_unstemmed | Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title_short | Sesamin from Cuscuta palaestina natural plant extracts: Directions for new prospective applications |
title_sort | sesamin from cuscuta palaestina natural plant extracts: directions for new prospective applications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892908/ https://www.ncbi.nlm.nih.gov/pubmed/29634770 http://dx.doi.org/10.1371/journal.pone.0195707 |
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