Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors

The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI). This results in phosphorylation of eIF2 and reduced eIF2 availability, which inhibits...

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Detalles Bibliográficos
Autores principales: Paolini, Nahuel A., Moore, Kat S., di Summa, Franca M., Fokkema, Ivo F. A. C., ‘t Hoen, Peter A. C., von Lindern, Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892948/
https://www.ncbi.nlm.nih.gov/pubmed/29634759
http://dx.doi.org/10.1371/journal.pone.0193790

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