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Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus

We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were...

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Autores principales: Cheng, Bi-Wen, Lo, Fu-Sung, Wang, An-Mei, Hung, Chen-Mei, Huang, Chi-Yu, Ting, Wei-Hsin, Yang, Mei-Ore, Lin, Chao-Hsu, Chen, Chia-Ching, Lin, Chiung-Ling, Wu, Yi-Lei, Lee, Yann-Jinn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893239/
https://www.ncbi.nlm.nih.gov/pubmed/29662644
http://dx.doi.org/10.18632/oncotarget.24527
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author Cheng, Bi-Wen
Lo, Fu-Sung
Wang, An-Mei
Hung, Chen-Mei
Huang, Chi-Yu
Ting, Wei-Hsin
Yang, Mei-Ore
Lin, Chao-Hsu
Chen, Chia-Ching
Lin, Chiung-Ling
Wu, Yi-Lei
Lee, Yann-Jinn
author_facet Cheng, Bi-Wen
Lo, Fu-Sung
Wang, An-Mei
Hung, Chen-Mei
Huang, Chi-Yu
Ting, Wei-Hsin
Yang, Mei-Ore
Lin, Chao-Hsu
Chen, Chia-Ching
Lin, Chiung-Ling
Wu, Yi-Lei
Lee, Yann-Jinn
author_sort Cheng, Bi-Wen
collection PubMed
description We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by χ(2) test, binary logistic regression, and Spearman rank correlation. Of the 750 T1D patients, 66.3% had GADA, 65.3% IA2A, 35.7% IAA, and 17.2% no autoantibodies. The prevalence of GADA and IA2A significantly decreased along T1D duration. The positivity of either GADA or IA2A was 89.4% within the first year of disease and decreased to 36.7% after 9 years (P = 1.22 × 10(–20)). Female patients had significantly higher prevalence of GADA compared with male patients (72.3% vs. 59.7%, P = 0.00027). The patients diagnosed before 12 years of age had a positive rate of 92.2% for either GADA or IA2A. Patients diagnosed at age 12 or above had a significantly lower positive rate of 81.6% (P = 0.011). GADA and IA2A significantly correlated with each other (rs = 0.245, P = 1.09 × 10(–11)). We concluded that autoantibodies were detectable in 89.4% of T1D patients within one year after diagnosis. Their prevalence declined with disease duration. GADA was more prevalent in female patients. GADA and IA2A weakly correlated with each other.
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spelling pubmed-58932392018-04-16 Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus Cheng, Bi-Wen Lo, Fu-Sung Wang, An-Mei Hung, Chen-Mei Huang, Chi-Yu Ting, Wei-Hsin Yang, Mei-Ore Lin, Chao-Hsu Chen, Chia-Ching Lin, Chiung-Ling Wu, Yi-Lei Lee, Yann-Jinn Oncotarget Research Paper: Immunology We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 autoantibody (IA2A), and insulin autoantibody (IAA) in 750 children with type 1 diabetes (T1D) living in Taiwan. GADA, IA2A, and IAA were measured by radioimmunoassay. The data were assessed by χ(2) test, binary logistic regression, and Spearman rank correlation. Of the 750 T1D patients, 66.3% had GADA, 65.3% IA2A, 35.7% IAA, and 17.2% no autoantibodies. The prevalence of GADA and IA2A significantly decreased along T1D duration. The positivity of either GADA or IA2A was 89.4% within the first year of disease and decreased to 36.7% after 9 years (P = 1.22 × 10(–20)). Female patients had significantly higher prevalence of GADA compared with male patients (72.3% vs. 59.7%, P = 0.00027). The patients diagnosed before 12 years of age had a positive rate of 92.2% for either GADA or IA2A. Patients diagnosed at age 12 or above had a significantly lower positive rate of 81.6% (P = 0.011). GADA and IA2A significantly correlated with each other (rs = 0.245, P = 1.09 × 10(–11)). We concluded that autoantibodies were detectable in 89.4% of T1D patients within one year after diagnosis. Their prevalence declined with disease duration. GADA was more prevalent in female patients. GADA and IA2A weakly correlated with each other. Impact Journals LLC 2018-02-19 /pmc/articles/PMC5893239/ /pubmed/29662644 http://dx.doi.org/10.18632/oncotarget.24527 Text en Copyright: © 2018 Cheng et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Immunology
Cheng, Bi-Wen
Lo, Fu-Sung
Wang, An-Mei
Hung, Chen-Mei
Huang, Chi-Yu
Ting, Wei-Hsin
Yang, Mei-Ore
Lin, Chao-Hsu
Chen, Chia-Ching
Lin, Chiung-Ling
Wu, Yi-Lei
Lee, Yann-Jinn
Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title_full Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title_fullStr Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title_full_unstemmed Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title_short Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
title_sort autoantibodies against islet cell antigens in children with type 1 diabetes mellitus
topic Research Paper: Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893239/
https://www.ncbi.nlm.nih.gov/pubmed/29662644
http://dx.doi.org/10.18632/oncotarget.24527
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