A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Development of a highly effective vaccine or antibodies for prevention and ultimately elimination of malaria is urgently needed. Here, we report the isolation of a number of human monoclonal antibodies (mAbs) directed against the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) from several...

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Detalles Bibliográficos
Autores principales: Kisalu, Neville K., Idris, Azza H., Weidle, Connor, Flores-Garcia, Yevel, Flynn, Barbara J., Sack, Brandon K., Murphy, Sean, Schön, Arne, Freire, Ernesto, Francica, Joseph R., Miller, Alex B., Gregory, Jason, March, Sandra, Liao, Hua-Xin, Haynes, Barton F., Wiehe, Kevin, Trama, Ashley M., Saunders, Kevin O., Gladden, Morgan A., Monroe, Anthony, Bonsignori, Mattia, Kanekiyo, Masaru, Wheatley, Adam K., McDermott, Adrian B., Farney, S. Katie, Chuang, Gwo-Yu, Zhang, Baoshan, Natasha, K C, Chakravarty, Sumana, Kwong, Peter D., Sinnis, Photini, Bhatia, Sangeeta N., Kappe, Stefan H. I., Sim, B. Kim Lee, Hoffman, Stephen L., Zavala, Fidel, Pancera, Marie, Seder, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893371/
https://www.ncbi.nlm.nih.gov/pubmed/29554083
http://dx.doi.org/10.1038/nm.4512

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