The role of Next-Generation Sequencing in tumoral radiosensitivity prediction

Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system bio...

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Detalles Bibliográficos
Autores principales: Bibault, Jean-Emmanuel, Tinhofer, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893518/
https://www.ncbi.nlm.nih.gov/pubmed/29658008
http://dx.doi.org/10.1016/j.ctro.2017.03.002
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author Bibault, Jean-Emmanuel
Tinhofer, Ingeborg
author_facet Bibault, Jean-Emmanuel
Tinhofer, Ingeborg
author_sort Bibault, Jean-Emmanuel
collection PubMed
description Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.
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spelling pubmed-58935182018-04-13 The role of Next-Generation Sequencing in tumoral radiosensitivity prediction Bibault, Jean-Emmanuel Tinhofer, Ingeborg Clin Transl Radiat Oncol Article Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity. Elsevier 2017-04-09 /pmc/articles/PMC5893518/ /pubmed/29658008 http://dx.doi.org/10.1016/j.ctro.2017.03.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bibault, Jean-Emmanuel
Tinhofer, Ingeborg
The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title_full The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title_fullStr The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title_full_unstemmed The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title_short The role of Next-Generation Sequencing in tumoral radiosensitivity prediction
title_sort role of next-generation sequencing in tumoral radiosensitivity prediction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893518/
https://www.ncbi.nlm.nih.gov/pubmed/29658008
http://dx.doi.org/10.1016/j.ctro.2017.03.002
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