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Mechanistic insights into allosteric regulation of the A(2A) adenosine G protein-coupled receptor by physiological cations
Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their mechanisms are poorly understood. Here, (19)F NMR is used to delineate the effects of cations on functional states of the adenosine A(2A) GPCR. While Na(+) reinforces an inactive ensemble and a partial-agonist s...
Autores principales: | Ye, Libin, Neale, Chris, Sljoka, Adnan, Lyda, Brent, Pichugin, Dmitry, Tsuchimura, Nobuyuki, Larda, Sacha T., Pomès, Régis, García, Angel E., Ernst, Oliver P., Sunahara, Roger K., Prosser, R. Scott |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893540/ https://www.ncbi.nlm.nih.gov/pubmed/29636462 http://dx.doi.org/10.1038/s41467-018-03314-9 |
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