Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. H...

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Detalles Bibliográficos
Autores principales: Joas, Simone, Parrish, Erica H., Gnanadurai, Clement W., Lump, Edina, Stürzel, Christina M., Parrish, Nicholas F., Learn, Gerald H., Sauermann, Ulrike, Neumann, Berit, Rensing, Kerstin Mätz, Fuchs, Dietmar, Billingsley, James M., Bosinger, Steven E., Silvestri, Guido, Apetrei, Cristian, Huot, Nicolas, Garcia-Tellez, Thalia, Müller-Trutwin, Michaela, Hotter, Dominik, Sauter, Daniel, Stahl-Hennig, Christiane, Hahn, Beatrice H., Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893559/
https://www.ncbi.nlm.nih.gov/pubmed/29636452
http://dx.doi.org/10.1038/s41467-018-03762-3

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