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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutati...

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Detalles Bibliográficos
Autores principales:	Chen, Li, Yang, Liu, Yao, Ling, Kuang, Xia-Ying, Zuo, Wen-Jia, Li, Shan, Qiao, Feng, Liu, Yi-Rong, Cao, Zhi-Gang, Zhou, Shu-Ling, Zhou, Xiao-Yan, Yang, Wen-Tao, Shi, Jin-Xiu, Huang, Wei, Hu, Xin, Shao, Zhi-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893593/ https://www.ncbi.nlm.nih.gov/pubmed/29636477 http://dx.doi.org/10.1038/s41467-018-03867-9

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