Cargando…

Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring

Pancreatic β-cells are exquisitely sensitive to developmental nutrient stressors, and alterations in nutrient sensing pathways may underlie changes observed in these models. Here we developed a mouse model of in utero exposure to the anti-diabetic agent metformin. We have previously shown that this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gregg, Brigid E., Botezatu, Nathalie, Brill, Joshua D., Hafner, Hannah, Vadrevu, Suryakiran, Satin, Leslie S., Alejandro, Emilyn U., Bernal-Mizrachi, Ernesto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893596/ https://www.ncbi.nlm.nih.gov/pubmed/29636523 http://dx.doi.org/10.1038/s41598-018-23965-4

Ejemplares similares

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass
por: Alejandro, Emilyn U., et al.
Publicado: (2017)

Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice
por: Jo, Seokwon, et al.
Publicado: (2023)

Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice
por: Akhaphong, Brian, et al.
Publicado: (2022)

Fractalkine signaling in regulation of insulin secretion: Mechanisms and potential therapeutic implications?
por: Gregg, Brigid, et al.
Publicado: (2014)

Upregulation of an inward rectifying K(+) channel can rescue slow Ca(2+) oscillations in K(ATP) channel deficient pancreatic islets
por: Yildirim, Vehpi, et al.
Publicado: (2017)

Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment
por: Hafner, Hannah, et al.
Publicado: (2021)

Cell death–associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress
por: Morishita, Yoshiaki, et al.
Publicado: (2021)

Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation
por: Chang, E., et al.
Publicado: (2019)

Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development
por: Elghazi, Lynda, et al.
Publicado: (2017)

Long-term effects of metformin use in gestational diabetes mellitus on offspring health
por: Roy, Ayan, et al.
Publicado: (2021)

Closing in on the Mechanisms of Pulsatile Insulin Secretion
por: Bertram, Richard, et al.
Publicado: (2018)

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
por: Montemurro, Chiara, et al.
Publicado: (2019)

Publisher Correction: IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
por: Montemurro, Chiara, et al.
Publicado: (2019)

Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring
por: Hafner, Hannah, et al.
Publicado: (2019)

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse
por: Head, W. Steven, et al.
Publicado: (2012)

Metformin in Gestational Diabetes: The Offspring Follow-Up (MiG TOFU): Body composition at 2 years of age
por: Rowan, Janet A., et al.
Publicado: (2011)

Metformin in Gestational Diabetes Mellitus
por: Reece, Sara Wilson, et al.
Publicado: (2014)

Metformin in gestational diabetes mellitus
por: Tripathi, Reva, et al.
Publicado: (2017)

Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring
por: Beetch, Megan, et al.
Publicado: (2021)

Associations of Gestational Glucose Tolerance With Offspring Body Composition and Estimated Insulin Resistance in Early Adolescence
por: Gingras, Véronique, et al.
Publicado: (2018)

Metformin in gestational diabetes: An emerging contender
por: Singh, Awadhesh Kumar, et al.
Publicado: (2015)

Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7–9 years of age
por: Rowan, Janet A, et al.
Publicado: (2018)

Maternal Metformin Treatment during Gestation and Lactation Improves Skeletal Muscle Development in Offspring of Rat Dams Fed High-Fat Diet
por: Cui, Jiaqi, et al.
Publicado: (2021)

How Metformin Acts in PCOS Pregnant Women: Insights into insulin secretion and peripheral action at each trimester of gestation
por: Romualdi, Daniela, et al.
Publicado: (2013)

LBSUN310 Developmental Programming: Gestational Bpa Treatment Leads To Pancreatic Beta Cell Compromise
por: Ciarelli, Joseph, et al.
Publicado: (2022)

Review of metformin and glyburide in the management of gestational diabetes
por: Carroll, Dana G., et al.
Publicado: (2014)

Metformin during Pregnancy: Effects on Offspring Development and Metabolic Function
por: Jorquera, Gonzalo, et al.
Publicado: (2020)

In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood
por: Faure, Mélanie C., et al.
Publicado: (2021)

Leukocyte Telomere Length in the Neonatal Offspring of Mothers with Gestational and Pre-Gestational Diabetes
por: Gilfillan, Christopher, et al.
Publicado: (2016)

Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring
por: Nahavandi, Sofia, et al.
Publicado: (2019)

Pharmacological Properties and Functional Role of K(slow) Current in Mouse Pancreatic β-Cells: SK Channels Contribute to K(slow) Tail Current and Modulate Insulin Secretion
por: Zhang, Min, et al.
Publicado: (2005)

The Preventive Effect of Zuogui Wan on Offspring Rats' Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus
por: Wang, Yuwei, et al.
Publicado: (2016)

Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
por: Yang, Sae Jeong, et al.
Publicado: (2013)

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring
por: Moore, Mackenzie, et al.
Publicado: (2021)

Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams
por: Chung, Grace, et al.
Publicado: (2022)

Predictors of metformin monotherapy failure in gestational diabetes mellitus
por: Benido Silva, Vânia, et al.
Publicado: (2022)

Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question
por: Tocci, Vera, et al.
Publicado: (2023)

Maternal Obesity, Gestational Weight Gain, and Asthma in Offspring
por: Polinski, Kristen J., et al.
Publicado: (2017)

Gestational diabetes mellitus, epigenetic age and offspring metabolism
por: Kim, Catherine, et al.
Publicado: (2022)

Metformin mitigates the impaired development of skeletal muscle in the offspring of obese mice
por: Tong, J F, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_cro1cp0ecdc158isiikfd8k7si