Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome

The proteasome is a sophisticated ATP-dependent molecular machine responsible for protein degradation in all known eukaryotic cells. It remains elusive how conformational changes of the AAA-ATPase unfoldase in the regulatory particle (RP) control the gating of the substrate–translocation channel lea...

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Detalles Bibliográficos
Autores principales: Zhu, Yanan, Wang, Wei Li, Yu, Daqi, Ouyang, Qi, Lu, Ying, Mao, Youdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893597/
https://www.ncbi.nlm.nih.gov/pubmed/29636472
http://dx.doi.org/10.1038/s41467-018-03785-w

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