Cargando…

Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels

Models mimicking the realistic geometries and mechanical properties of human tissue are requiring ever-better materials. Biomodels made of poly (vinyl alcohol) are particularly in demand, as they can be used to realistically reproduce the characteristics of blood vessels. The reproducibility of biom...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimizu, Yasutomo, Putra, Narendra Kurnia, Ohta, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893614/
https://www.ncbi.nlm.nih.gov/pubmed/29636533
http://dx.doi.org/10.1038/s41598-018-24235-z
_version_ 1783313335797678080
author Shimizu, Yasutomo
Putra, Narendra Kurnia
Ohta, Makoto
author_facet Shimizu, Yasutomo
Putra, Narendra Kurnia
Ohta, Makoto
author_sort Shimizu, Yasutomo
collection PubMed
description Models mimicking the realistic geometries and mechanical properties of human tissue are requiring ever-better materials. Biomodels made of poly (vinyl alcohol) are particularly in demand, as they can be used to realistically reproduce the characteristics of blood vessels. The reproducibility of biomodels can be altered due to dehydration that is observed after long periods of usage. In order to improve their usability, one should consider the method used to reproduce them; however, few studies have reported a method reproduce biomodels. This study proposes a novel reproduction method for biomodels that allows them to quickly and easily reproduce their geometric and mechanical properties. Specimens of the dried biomodels were reformed through immersion in temperature-controlled water. Our results show that water at 35 °C can be effective to reproduce both the geometric and mechanical properties of the specimens. X-ray diffraction (XRD) measurements revealed that water immersion can reform the crystal structure of the pre-dried specimens, and images obtained using micro-computed tomography acquisition show that the geometry of the specimens can be reformed by water immersion without introducing any defects. These results indicate that the proposed method can lead to high reproducibility of both the original geometric and mechanical properties of the dried biomodels.
format Online
Article
Text
id pubmed-5893614
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-58936142018-04-12 Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels Shimizu, Yasutomo Putra, Narendra Kurnia Ohta, Makoto Sci Rep Article Models mimicking the realistic geometries and mechanical properties of human tissue are requiring ever-better materials. Biomodels made of poly (vinyl alcohol) are particularly in demand, as they can be used to realistically reproduce the characteristics of blood vessels. The reproducibility of biomodels can be altered due to dehydration that is observed after long periods of usage. In order to improve their usability, one should consider the method used to reproduce them; however, few studies have reported a method reproduce biomodels. This study proposes a novel reproduction method for biomodels that allows them to quickly and easily reproduce their geometric and mechanical properties. Specimens of the dried biomodels were reformed through immersion in temperature-controlled water. Our results show that water at 35 °C can be effective to reproduce both the geometric and mechanical properties of the specimens. X-ray diffraction (XRD) measurements revealed that water immersion can reform the crystal structure of the pre-dried specimens, and images obtained using micro-computed tomography acquisition show that the geometry of the specimens can be reformed by water immersion without introducing any defects. These results indicate that the proposed method can lead to high reproducibility of both the original geometric and mechanical properties of the dried biomodels. Nature Publishing Group UK 2018-04-10 /pmc/articles/PMC5893614/ /pubmed/29636533 http://dx.doi.org/10.1038/s41598-018-24235-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Shimizu, Yasutomo
Putra, Narendra Kurnia
Ohta, Makoto
Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title_full Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title_fullStr Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title_full_unstemmed Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title_short Reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
title_sort reproduction method for dried biomodels composed of poly (vinyl alcohol) hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893614/
https://www.ncbi.nlm.nih.gov/pubmed/29636533
http://dx.doi.org/10.1038/s41598-018-24235-z
work_keys_str_mv AT shimizuyasutomo reproductionmethodfordriedbiomodelscomposedofpolyvinylalcoholhydrogels
AT putranarendrakurnia reproductionmethodfordriedbiomodelscomposedofpolyvinylalcoholhydrogels
AT ohtamakoto reproductionmethodfordriedbiomodelscomposedofpolyvinylalcoholhydrogels