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Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex

Homoserine dehydrogenase (EC 1.1.1.3, HSD) is an important regulatory enzyme in the aspartate pathway, which mediates synthesis of methionine, threonine and isoleucine from aspartate. Here, HSD from the hyperthermophilic archaeon Sulfolobus tokodaii (StHSD) was found to be inhibited by cysteine, whi...

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Detalles Bibliográficos
Autores principales:	Ogata, Kohei, Yajima, Yui, Nakamura, Sanenori, Kaneko, Ryosuke, Goto, Masaru, Ohshima, Toshihisa, Yoshimune, Kazuaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893615/ https://www.ncbi.nlm.nih.gov/pubmed/29636528 http://dx.doi.org/10.1038/s41598-018-24063-1

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