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Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature

In this review, we summarized three cases of myasthenia gravis (MG) with taste disorder and describe their clinical features in detail. Three MG patients presented with significant bulbar palsy symptoms, high AChR-Ab titers, and negative MuSK-Ab, were diagnosed with thymoma. Furthermore, we observed...

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Autores principales: Zhu, Kai, Chen, Jiaxin, Li, Jingjing, Wang, Haiyan, Huang, Xin, Li, Yan, Feng, Huiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893777/
https://www.ncbi.nlm.nih.gov/pubmed/29670572
http://dx.doi.org/10.3389/fneur.2018.00214
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author Zhu, Kai
Chen, Jiaxin
Li, Jingjing
Wang, Haiyan
Huang, Xin
Li, Yan
Feng, Huiyu
author_facet Zhu, Kai
Chen, Jiaxin
Li, Jingjing
Wang, Haiyan
Huang, Xin
Li, Yan
Feng, Huiyu
author_sort Zhu, Kai
collection PubMed
description In this review, we summarized three cases of myasthenia gravis (MG) with taste disorder and describe their clinical features in detail. Three MG patients presented with significant bulbar palsy symptoms, high AChR-Ab titers, and negative MuSK-Ab, were diagnosed with thymoma. Furthermore, we observed that dysgeusia could manifest earlier than the occurrence of typical MG symptoms, even predict a MG relapse or a myasthenic crisis in the course of MG. We believe that dysgeusia is a non-motor symptom of MG, which especially exists in MG patients with thymoma and serious bulbar palsy. Therefore, being alert to this symptom may facilitate the early diagnosis of MG and judge the progress of the disease.
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spelling pubmed-58937772018-04-18 Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature Zhu, Kai Chen, Jiaxin Li, Jingjing Wang, Haiyan Huang, Xin Li, Yan Feng, Huiyu Front Neurol Neuroscience In this review, we summarized three cases of myasthenia gravis (MG) with taste disorder and describe their clinical features in detail. Three MG patients presented with significant bulbar palsy symptoms, high AChR-Ab titers, and negative MuSK-Ab, were diagnosed with thymoma. Furthermore, we observed that dysgeusia could manifest earlier than the occurrence of typical MG symptoms, even predict a MG relapse or a myasthenic crisis in the course of MG. We believe that dysgeusia is a non-motor symptom of MG, which especially exists in MG patients with thymoma and serious bulbar palsy. Therefore, being alert to this symptom may facilitate the early diagnosis of MG and judge the progress of the disease. Frontiers Media S.A. 2018-04-04 /pmc/articles/PMC5893777/ /pubmed/29670572 http://dx.doi.org/10.3389/fneur.2018.00214 Text en Copyright © 2018 Zhu, Chen, Li, Wang, Huang, Li and Feng. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhu, Kai
Chen, Jiaxin
Li, Jingjing
Wang, Haiyan
Huang, Xin
Li, Yan
Feng, Huiyu
Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title_full Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title_fullStr Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title_full_unstemmed Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title_short Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
title_sort myasthenia gravis with thymoma, manifesting as achr-ab-positive, distinct bulbar palsy accompanied by dysgeusia: a case series and review of literature
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893777/
https://www.ncbi.nlm.nih.gov/pubmed/29670572
http://dx.doi.org/10.3389/fneur.2018.00214
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