The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule

Francisella tularensis is a highly infectious Gram-negative bacterium that is the etiologic agent of tularemia in animals and humans and a Tier 1 select agent. The natural incidence of pneumonic tularemia worldwide is very low; therefore, it is not feasible to conduct clinical efficacy testing of tu...

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Detalles Bibliográficos
Autores principales: Guina, Tina, Lanning, Lynda L., Omland, Kristian S., Williams, Mark S., Wolfraim, Larry A., Heyse, Stephen P., Houchens, Christopher R., Sanz, Patrick, Hewitt, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893833/
https://www.ncbi.nlm.nih.gov/pubmed/29670861
http://dx.doi.org/10.3389/fcimb.2018.00099

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