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Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention
OBJECTIVES: To compare follicular reduction prior to human chorionic gonadotropin (HCG) trigger and coasting in terms of ovarian hyper-stimulation syndrome (OHSS) reduction, pregnancy, and cancellation rates in in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. METHODS: This...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893919/ https://www.ncbi.nlm.nih.gov/pubmed/29543308 http://dx.doi.org/10.15537/smj.2018.3.22331 |
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author | Bushaqer, Nayla J. Dayoub, Nawal M. AlHattali, Khalsa K. Ayyoub, Hisham A. AlFaraj, Samaher S. Hassan, Samar N. |
author_facet | Bushaqer, Nayla J. Dayoub, Nawal M. AlHattali, Khalsa K. Ayyoub, Hisham A. AlFaraj, Samaher S. Hassan, Samar N. |
author_sort | Bushaqer, Nayla J. |
collection | PubMed |
description | OBJECTIVES: To compare follicular reduction prior to human chorionic gonadotropin (HCG) trigger and coasting in terms of ovarian hyper-stimulation syndrome (OHSS) reduction, pregnancy, and cancellation rates in in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. METHODS: This study was designed as a prospective study. The setting was the IVF unit at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. A total of 39 patients undergoing IVF/ICSI cycles, who were at risk of OHSS, 20 were put into a coasting group and 19 had follicular reduction instead. This occurred between October 2010 and January 2011. Our main outcome was OHSS reduction. RESULTS: Six (30%) women developed OHSS in the coasting group and 2 (10.5%) women developed OHSS in the follicular group (p-value=0.235). The pregnancy rates in the cycles were similar for both groups: 4/20 (20%) in the coasting group and 3/19 (15.8%) in the follicular group (p-value=1.000). The cancellation rate of the cycles was similar for both groups, 6/20 (30%) in the coasting group and 1/19 (5.3%) in the follicular group (p-value=0.09). The median number of punctured follicles was significantly lower in the follicular group (16 follicles, interquartile range (IQR)=21-12) compared to the coasting group (29 follicles, IQR=37.8-19.8, p-value=0.001). The retrieved, fertilized, and cleaved oocytes, as well as the number of embryos transferred, were similar amongst both groups. CONCLUSION: There was no difference between follicular reduction prior to HCG and coasting, in terms of OHSS reduction, pregnancy, and cancellation rates in both the IVF and ICSI cycles. |
format | Online Article Text |
id | pubmed-5893919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-58939192018-04-16 Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention Bushaqer, Nayla J. Dayoub, Nawal M. AlHattali, Khalsa K. Ayyoub, Hisham A. AlFaraj, Samaher S. Hassan, Samar N. Saudi Med J Original Article OBJECTIVES: To compare follicular reduction prior to human chorionic gonadotropin (HCG) trigger and coasting in terms of ovarian hyper-stimulation syndrome (OHSS) reduction, pregnancy, and cancellation rates in in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. METHODS: This study was designed as a prospective study. The setting was the IVF unit at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. A total of 39 patients undergoing IVF/ICSI cycles, who were at risk of OHSS, 20 were put into a coasting group and 19 had follicular reduction instead. This occurred between October 2010 and January 2011. Our main outcome was OHSS reduction. RESULTS: Six (30%) women developed OHSS in the coasting group and 2 (10.5%) women developed OHSS in the follicular group (p-value=0.235). The pregnancy rates in the cycles were similar for both groups: 4/20 (20%) in the coasting group and 3/19 (15.8%) in the follicular group (p-value=1.000). The cancellation rate of the cycles was similar for both groups, 6/20 (30%) in the coasting group and 1/19 (5.3%) in the follicular group (p-value=0.09). The median number of punctured follicles was significantly lower in the follicular group (16 follicles, interquartile range (IQR)=21-12) compared to the coasting group (29 follicles, IQR=37.8-19.8, p-value=0.001). The retrieved, fertilized, and cleaved oocytes, as well as the number of embryos transferred, were similar amongst both groups. CONCLUSION: There was no difference between follicular reduction prior to HCG and coasting, in terms of OHSS reduction, pregnancy, and cancellation rates in both the IVF and ICSI cycles. Saudi Medical Journal 2018-03 /pmc/articles/PMC5893919/ /pubmed/29543308 http://dx.doi.org/10.15537/smj.2018.3.22331 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bushaqer, Nayla J. Dayoub, Nawal M. AlHattali, Khalsa K. Ayyoub, Hisham A. AlFaraj, Samaher S. Hassan, Samar N. Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title | Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title_full | Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title_fullStr | Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title_full_unstemmed | Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title_short | Follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
title_sort | follicular aspiration versus coasting for ovarian hyper-stimulation syndrome prevention |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893919/ https://www.ncbi.nlm.nih.gov/pubmed/29543308 http://dx.doi.org/10.15537/smj.2018.3.22331 |
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