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Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination
INTRODUCTION: To reduce the pertussis disease burden, nowadays several countries recommend acellular pertussis (aP) booster vaccinations for adults. We aimed to evaluate the immunogenicity of a first adult aP booster vaccination at childbearing age. METHODS: In 2014, healthy adults aged 25–29 years...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893963/ https://www.ncbi.nlm.nih.gov/pubmed/29670634 http://dx.doi.org/10.3389/fimmu.2018.00681 |
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author | van der Lee, Saskia van Rooijen, Debbie M. de Zeeuw-Brouwer, Mary-Lène Bogaard, Marjan J. M. van Gageldonk, Pieter G. M. Marinovic, Axel Bonacic Sanders, Elisabeth A. M. Berbers, Guy A. M. Buisman, Anne-Marie |
author_facet | van der Lee, Saskia van Rooijen, Debbie M. de Zeeuw-Brouwer, Mary-Lène Bogaard, Marjan J. M. van Gageldonk, Pieter G. M. Marinovic, Axel Bonacic Sanders, Elisabeth A. M. Berbers, Guy A. M. Buisman, Anne-Marie |
author_sort | van der Lee, Saskia |
collection | PubMed |
description | INTRODUCTION: To reduce the pertussis disease burden, nowadays several countries recommend acellular pertussis (aP) booster vaccinations for adults. We aimed to evaluate the immunogenicity of a first adult aP booster vaccination at childbearing age. METHODS: In 2014, healthy adults aged 25–29 years (n = 105), vaccinated during infancy with four doses of whole-cell pertussis (wP) vaccine, received a Tdap (tetanus, diphtheria, and aP) booster vaccination. Blood samples were collected longitudinally pre-booster, 2 and 4 weeks, and 1 year and 2 years post-booster. Tdap vaccine antigen-specific antibody levels and memory B- and T-cell responses were determined at all time points. Antibody persistence was calculated using a bi-exponential decay model. RESULTS: Upon booster vaccination, the IgG levels specific to all Tdap vaccine antigens were significantly increased. After an initial rapid decline in the first year, PT-IgG antibody decay was limited (15%) in the second year post-booster. The duration of a median level of PT-IgG ≥20 IU/mL was estimated to be approximately 9 years. Vaccine antigen-specific memory B- and T-cell numbers increased and remained at high levels although a significant decline was observed after 4 weeks post-booster. However, Th1, Th2, and Th17 cytokine production remained above pre-booster levels for 2 years. CONCLUSION: The Tdap booster vaccination in wP-primed Dutch adults induced robust long-term humoral and cellular immune responses to pertussis antigens. Furthermore, PT-IgG levels are predicted to remain above the presumed protective cut-off for at least 9 years which might deserves further attention in evaluating the current recommendation to revaccinate women during every new pregnancy. |
format | Online Article Text |
id | pubmed-5893963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58939632018-04-18 Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination van der Lee, Saskia van Rooijen, Debbie M. de Zeeuw-Brouwer, Mary-Lène Bogaard, Marjan J. M. van Gageldonk, Pieter G. M. Marinovic, Axel Bonacic Sanders, Elisabeth A. M. Berbers, Guy A. M. Buisman, Anne-Marie Front Immunol Immunology INTRODUCTION: To reduce the pertussis disease burden, nowadays several countries recommend acellular pertussis (aP) booster vaccinations for adults. We aimed to evaluate the immunogenicity of a first adult aP booster vaccination at childbearing age. METHODS: In 2014, healthy adults aged 25–29 years (n = 105), vaccinated during infancy with four doses of whole-cell pertussis (wP) vaccine, received a Tdap (tetanus, diphtheria, and aP) booster vaccination. Blood samples were collected longitudinally pre-booster, 2 and 4 weeks, and 1 year and 2 years post-booster. Tdap vaccine antigen-specific antibody levels and memory B- and T-cell responses were determined at all time points. Antibody persistence was calculated using a bi-exponential decay model. RESULTS: Upon booster vaccination, the IgG levels specific to all Tdap vaccine antigens were significantly increased. After an initial rapid decline in the first year, PT-IgG antibody decay was limited (15%) in the second year post-booster. The duration of a median level of PT-IgG ≥20 IU/mL was estimated to be approximately 9 years. Vaccine antigen-specific memory B- and T-cell numbers increased and remained at high levels although a significant decline was observed after 4 weeks post-booster. However, Th1, Th2, and Th17 cytokine production remained above pre-booster levels for 2 years. CONCLUSION: The Tdap booster vaccination in wP-primed Dutch adults induced robust long-term humoral and cellular immune responses to pertussis antigens. Furthermore, PT-IgG levels are predicted to remain above the presumed protective cut-off for at least 9 years which might deserves further attention in evaluating the current recommendation to revaccinate women during every new pregnancy. Frontiers Media S.A. 2018-04-04 /pmc/articles/PMC5893963/ /pubmed/29670634 http://dx.doi.org/10.3389/fimmu.2018.00681 Text en Copyright © 2018 van der Lee, van Rooijen, de Zeeuw-Brouwer, Bogaard, van Gageldonk, Marinovic, Sanders, Berbers and Buisman. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology van der Lee, Saskia van Rooijen, Debbie M. de Zeeuw-Brouwer, Mary-Lène Bogaard, Marjan J. M. van Gageldonk, Pieter G. M. Marinovic, Axel Bonacic Sanders, Elisabeth A. M. Berbers, Guy A. M. Buisman, Anne-Marie Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title | Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title_full | Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title_fullStr | Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title_full_unstemmed | Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title_short | Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination |
title_sort | robust humoral and cellular immune responses to pertussis in adults after a first acellular booster vaccination |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893963/ https://www.ncbi.nlm.nih.gov/pubmed/29670634 http://dx.doi.org/10.3389/fimmu.2018.00681 |
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