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Association between oral lichen planus and Epstein–Barr virus in Iranian patients

BACKGROUND: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate...

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Autores principales: Shariati, Matin, Mokhtari, Mojgan, Masoudifar, Aria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894270/
https://www.ncbi.nlm.nih.gov/pubmed/29692821
http://dx.doi.org/10.4103/jrms.JRMS_438_17
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author Shariati, Matin
Mokhtari, Mojgan
Masoudifar, Aria
author_facet Shariati, Matin
Mokhtari, Mojgan
Masoudifar, Aria
author_sort Shariati, Matin
collection PubMed
description BACKGROUND: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein–Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. MATERIALS AND METHODS: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa. All samples were examined by nested polymerase chain reaction (PCR) method to determine the DNA of EBV. RESULTS: Twenty-two (57.9%) female samples and 16 (42.1%) male samples with OLP were randomly selected as the case group, and 20 (52.6%) female samples and 18 (47.4%) male samples with healthy mucosa as the control group. There was a statistically significant difference in the percentage of EBV positivity between the case (15.8%) and the control groups (P < 0.05); in the case group, three female samples (13.6%) and three male samples (18.8%) were infected with EBV; the difference between the genders was not statistically significant (P = 0.50). CONCLUSION: Results emphasized that EBV genome was significantly higher among Iranian patients with OLP so antiviral therapy might be helpful.
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spelling pubmed-58942702018-04-24 Association between oral lichen planus and Epstein–Barr virus in Iranian patients Shariati, Matin Mokhtari, Mojgan Masoudifar, Aria J Res Med Sci Original Article BACKGROUND: Oral lichen planus (OLP) is a common mucocutaneous disease with malignant transformation potential. Several etiologies such as humoral, autoimmunity, and viral infections might play a role, but still there is no definite etiology for this disease. The aim of this study was to investigate the presence of Epstein–Barr virus (EBV) genome in Iranian patients with OLP as compared to people with normal mucosa. MATERIALS AND METHODS: The study was carried out on a case group including 38 tissue specimens of patients with histopathological confirmation of OLP and a control group including 38 samples of healthy mucosa. All samples were examined by nested polymerase chain reaction (PCR) method to determine the DNA of EBV. RESULTS: Twenty-two (57.9%) female samples and 16 (42.1%) male samples with OLP were randomly selected as the case group, and 20 (52.6%) female samples and 18 (47.4%) male samples with healthy mucosa as the control group. There was a statistically significant difference in the percentage of EBV positivity between the case (15.8%) and the control groups (P < 0.05); in the case group, three female samples (13.6%) and three male samples (18.8%) were infected with EBV; the difference between the genders was not statistically significant (P = 0.50). CONCLUSION: Results emphasized that EBV genome was significantly higher among Iranian patients with OLP so antiviral therapy might be helpful. Medknow Publications & Media Pvt Ltd 2018-03-27 /pmc/articles/PMC5894270/ /pubmed/29692821 http://dx.doi.org/10.4103/jrms.JRMS_438_17 Text en Copyright: © 2018 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Shariati, Matin
Mokhtari, Mojgan
Masoudifar, Aria
Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title_full Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title_fullStr Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title_full_unstemmed Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title_short Association between oral lichen planus and Epstein–Barr virus in Iranian patients
title_sort association between oral lichen planus and epstein–barr virus in iranian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894270/
https://www.ncbi.nlm.nih.gov/pubmed/29692821
http://dx.doi.org/10.4103/jrms.JRMS_438_17
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