Cargando…

Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience

INTRODUCTION: Open radical cystectomy (RC) is associated with significant morbidity and the role of minimally invasive surgery (MIS) in reducing morbidity of RC is controversial A direct comparison of various surgical modalities on perioperative outcomes is lacking in the Indian literature. We evalu...

Descripción completa

Detalles Bibliográficos
Autores principales: Panwar, Pankaj, Mavuduru, Ravimohan S., Mete, Uttam Kumar, Kumar, Santosh, Bora, Girdhar Singh, Devana, Sudheer Kumar, Mandal, Arup Kumar, Singh, Shrawan Kumar, Kakkar, Nandita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894283/
https://www.ncbi.nlm.nih.gov/pubmed/29692504
http://dx.doi.org/10.4103/iju.IJU_166_17
_version_ 1783313468890284032
author Panwar, Pankaj
Mavuduru, Ravimohan S.
Mete, Uttam Kumar
Kumar, Santosh
Bora, Girdhar Singh
Devana, Sudheer Kumar
Mandal, Arup Kumar
Singh, Shrawan Kumar
Kakkar, Nandita
author_facet Panwar, Pankaj
Mavuduru, Ravimohan S.
Mete, Uttam Kumar
Kumar, Santosh
Bora, Girdhar Singh
Devana, Sudheer Kumar
Mandal, Arup Kumar
Singh, Shrawan Kumar
Kakkar, Nandita
author_sort Panwar, Pankaj
collection PubMed
description INTRODUCTION: Open radical cystectomy (RC) is associated with significant morbidity and the role of minimally invasive surgery (MIS) in reducing morbidity of RC is controversial A direct comparison of various surgical modalities on perioperative outcomes is lacking in the Indian literature. We evaluated outcomes of minimally invasive (robotic and laparoscopic) versus open RC with pelvic lymph node dissection (PLND) performed at our institute from 2014 to 2016. METHODS: Eighty-three patients of RC with PLND were prospectively analyzed from December 2014 to February 2016. All patients of muscle invasive urothelial cancer of the bladder undergoing RC (open or MIS) were included in the study. Based on patients preference they were assigned to one of the three groups (Open RC, robot-assisted RC, or laparoscopic RC). Their demographic profile, preoperative disease stage, operative data like operative time, blood loss, intraoperative complications, histopathological data like pathological stage, lymph-node yield etc., postoperative complications if any and total duration of stay were recorded. These data of laparoscopic, open, and robotic cystectomies were compared in terms of various demographic, histopathologic parameters and perioperative outcomes. RESULTS: Twenty-nine patients (34.93%) underwent minimally invasive RC with PLND (5 laparoscopic and 24 robotic). The median age of patients was 58 years. Mean number of lymph nodes removed was 22.5 ± 14.6. The total number of lymph nodes removed in laparoscopic surgery was 104 with a yield of 20.6 per patient, in robotic surgery were 627 with a yield of 26.1 per patient, and in open surgery were 1119 with a yield of 20.7 per patient (P = 0.004). Clavien-Dindo Grade 2 and 3 complications were seen in 37.5% of robotic, 60% of laparoscopic, and 55.54% of open RC. Average blood loss and operative time in laparoscopic, robotic, and open RC were 511.53 ± 311.02 ml, 552.08 ± 267.63 ml, and 512.05 ± 213.9 ml and 8.23 ± 1.36 h (hrs), 7.53 ± 1.92 h, and 5.85 ± 1.76 h, respectively (P = 0.68 and <0.001, respectively). CONCLUSIONS: MIS is associated with significantly longer operative time than open RC. Robotic RC has significantly higher lymph node yield than open or laparoscopic RC. Minimally invasive RC is equivalent to open surgery in terms of perioperative morbidity, mortality, and blood loss.
format Online
Article
Text
id pubmed-5894283
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-58942832018-04-24 Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience Panwar, Pankaj Mavuduru, Ravimohan S. Mete, Uttam Kumar Kumar, Santosh Bora, Girdhar Singh Devana, Sudheer Kumar Mandal, Arup Kumar Singh, Shrawan Kumar Kakkar, Nandita Indian J Urol Original Article INTRODUCTION: Open radical cystectomy (RC) is associated with significant morbidity and the role of minimally invasive surgery (MIS) in reducing morbidity of RC is controversial A direct comparison of various surgical modalities on perioperative outcomes is lacking in the Indian literature. We evaluated outcomes of minimally invasive (robotic and laparoscopic) versus open RC with pelvic lymph node dissection (PLND) performed at our institute from 2014 to 2016. METHODS: Eighty-three patients of RC with PLND were prospectively analyzed from December 2014 to February 2016. All patients of muscle invasive urothelial cancer of the bladder undergoing RC (open or MIS) were included in the study. Based on patients preference they were assigned to one of the three groups (Open RC, robot-assisted RC, or laparoscopic RC). Their demographic profile, preoperative disease stage, operative data like operative time, blood loss, intraoperative complications, histopathological data like pathological stage, lymph-node yield etc., postoperative complications if any and total duration of stay were recorded. These data of laparoscopic, open, and robotic cystectomies were compared in terms of various demographic, histopathologic parameters and perioperative outcomes. RESULTS: Twenty-nine patients (34.93%) underwent minimally invasive RC with PLND (5 laparoscopic and 24 robotic). The median age of patients was 58 years. Mean number of lymph nodes removed was 22.5 ± 14.6. The total number of lymph nodes removed in laparoscopic surgery was 104 with a yield of 20.6 per patient, in robotic surgery were 627 with a yield of 26.1 per patient, and in open surgery were 1119 with a yield of 20.7 per patient (P = 0.004). Clavien-Dindo Grade 2 and 3 complications were seen in 37.5% of robotic, 60% of laparoscopic, and 55.54% of open RC. Average blood loss and operative time in laparoscopic, robotic, and open RC were 511.53 ± 311.02 ml, 552.08 ± 267.63 ml, and 512.05 ± 213.9 ml and 8.23 ± 1.36 h (hrs), 7.53 ± 1.92 h, and 5.85 ± 1.76 h, respectively (P = 0.68 and <0.001, respectively). CONCLUSIONS: MIS is associated with significantly longer operative time than open RC. Robotic RC has significantly higher lymph node yield than open or laparoscopic RC. Minimally invasive RC is equivalent to open surgery in terms of perioperative morbidity, mortality, and blood loss. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5894283/ /pubmed/29692504 http://dx.doi.org/10.4103/iju.IJU_166_17 Text en Copyright: © 2017 Indian Journal of Urology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Panwar, Pankaj
Mavuduru, Ravimohan S.
Mete, Uttam Kumar
Kumar, Santosh
Bora, Girdhar Singh
Devana, Sudheer Kumar
Mandal, Arup Kumar
Singh, Shrawan Kumar
Kakkar, Nandita
Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title_full Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title_fullStr Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title_full_unstemmed Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title_short Perioperative outcomes of minimally invasive versus open radical cystectomy: A single-center experience
title_sort perioperative outcomes of minimally invasive versus open radical cystectomy: a single-center experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894283/
https://www.ncbi.nlm.nih.gov/pubmed/29692504
http://dx.doi.org/10.4103/iju.IJU_166_17
work_keys_str_mv AT panwarpankaj perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT mavudururavimohans perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT meteuttamkumar perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT kumarsantosh perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT boragirdharsingh perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT devanasudheerkumar perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT mandalarupkumar perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT singhshrawankumar perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience
AT kakkarnandita perioperativeoutcomesofminimallyinvasiveversusopenradicalcystectomyasinglecenterexperience