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DON-induced Changes in Bone Homeostasis in Mink Dams

INTRODUCTION: The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting. MATERIAL A...

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Autores principales: Tomaszewska, Ewa, Dobrowolski, Piotr, Muszyński, Siemowit, Kostro, Krzysztof, Taszkun, Iwona, Żmuda, Andrzej, Blicharski, Tomasz, Hułas-Stasiak, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894421/
https://www.ncbi.nlm.nih.gov/pubmed/29978095
http://dx.doi.org/10.1515/jvetres-2017-0047
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author Tomaszewska, Ewa
Dobrowolski, Piotr
Muszyński, Siemowit
Kostro, Krzysztof
Taszkun, Iwona
Żmuda, Andrzej
Blicharski, Tomasz
Hułas-Stasiak, Monika
author_facet Tomaszewska, Ewa
Dobrowolski, Piotr
Muszyński, Siemowit
Kostro, Krzysztof
Taszkun, Iwona
Żmuda, Andrzej
Blicharski, Tomasz
Hułas-Stasiak, Monika
author_sort Tomaszewska, Ewa
collection PubMed
description INTRODUCTION: The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting. MATERIAL AND METHODS: Thirty clinically healthy multiparous minks (Neovison vison) of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: non-treated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg(-1) of feed. RESULTS: The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties. CONCLUSION: DON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone.
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spelling pubmed-58944212018-07-05 DON-induced Changes in Bone Homeostasis in Mink Dams Tomaszewska, Ewa Dobrowolski, Piotr Muszyński, Siemowit Kostro, Krzysztof Taszkun, Iwona Żmuda, Andrzej Blicharski, Tomasz Hułas-Stasiak, Monika J Vet Res Research Article INTRODUCTION: The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting. MATERIAL AND METHODS: Thirty clinically healthy multiparous minks (Neovison vison) of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: non-treated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg(-1) of feed. RESULTS: The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties. CONCLUSION: DON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone. De Gruyter Open 2017-09-19 /pmc/articles/PMC5894421/ /pubmed/29978095 http://dx.doi.org/10.1515/jvetres-2017-0047 Text en © 2017 E. Tomaszewska et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivs license
spellingShingle Research Article
Tomaszewska, Ewa
Dobrowolski, Piotr
Muszyński, Siemowit
Kostro, Krzysztof
Taszkun, Iwona
Żmuda, Andrzej
Blicharski, Tomasz
Hułas-Stasiak, Monika
DON-induced Changes in Bone Homeostasis in Mink Dams
title DON-induced Changes in Bone Homeostasis in Mink Dams
title_full DON-induced Changes in Bone Homeostasis in Mink Dams
title_fullStr DON-induced Changes in Bone Homeostasis in Mink Dams
title_full_unstemmed DON-induced Changes in Bone Homeostasis in Mink Dams
title_short DON-induced Changes in Bone Homeostasis in Mink Dams
title_sort don-induced changes in bone homeostasis in mink dams
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894421/
https://www.ncbi.nlm.nih.gov/pubmed/29978095
http://dx.doi.org/10.1515/jvetres-2017-0047
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