Cargando…

Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China

PURPOSE: To investigate the association of age and sex on survival in non-metastatic colorectal cancer (CRC) patients and to identify groups at high risk for poor outcomes. MATERIALS AND METHODS: We performed a retrospective analysis of 5,047 non-metastatic CRC patients from 2008 to 2013. Data regar...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Lijun, Mo, Miao, Jia, Leon, Jia, Huixun, Li, Qingguo, Liang, Lei, Shi, Debing, Zhang, Zhen, Cai, Sanjun, Li, Xinxiang, Zhu, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894745/
https://www.ncbi.nlm.nih.gov/pubmed/29670399
http://dx.doi.org/10.2147/CMAR.S159901
_version_ 1783313547546066944
author Shen, Lijun
Mo, Miao
Jia, Leon
Jia, Huixun
Li, Qingguo
Liang, Lei
Shi, Debing
Zhang, Zhen
Cai, Sanjun
Li, Xinxiang
Zhu, Ji
author_facet Shen, Lijun
Mo, Miao
Jia, Leon
Jia, Huixun
Li, Qingguo
Liang, Lei
Shi, Debing
Zhang, Zhen
Cai, Sanjun
Li, Xinxiang
Zhu, Ji
author_sort Shen, Lijun
collection PubMed
description PURPOSE: To investigate the association of age and sex on survival in non-metastatic colorectal cancer (CRC) patients and to identify groups at high risk for poor outcomes. MATERIALS AND METHODS: We performed a retrospective analysis of 5,047 non-metastatic CRC patients from 2008 to 2013. Data regarding age at diagnosis; gender; tumor site; tumor stage; differentiation; lymphatic, neural or vascular invasion; and survival outcomes were collected. Patients were stratified into 10-year age groups (≤35, 36–45, 46–55, 56–65, 66–75, >75) and then further analyzed in three age groups (≤35, 36–75, >75). Disease-free survival (DFS) and overall survival (OS) were evaluated using univariate and multivariate Cox regression models. RESULTS: Of the 5,047 eligible patients, 41.3% were female. The tumor stages were balanced between the genders. In the female patients, the tumor stages were similarly distributed among the different age groups, while younger male patients were diagnosed with more advanced disease (P<0.001 for trend). When stratified into three age groups, young females experienced significantly poorer survival than young males (DFS: hazard ratio [HR]=1.85 [1.04–3.30], OS: HR=2.65 [1.11–6.34]). After adjusting for tumor stage, site, differentiated grade and lymphatic or vascular invasion status, females ≤35 and >75 had shorter DFS than patients between 36 and 75 years old (HR=1.57 [1.03–2.38] and HR=1.51 [1.11–2.05, respectively]), while there was no difference in DFS between females ≤35 and those >75. For male patients, older age was associated with poorer OS after the same adjustment. CONCLUSION: Young female CRC patients (≤35 years old) had the poorest DFS and quite poor OS compared to the other age groups. This emphasizes the need for health care providers to have a heightened awareness and to conduct further research when caring for young female CRC patients.
format Online
Article
Text
id pubmed-5894745
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-58947452018-04-18 Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China Shen, Lijun Mo, Miao Jia, Leon Jia, Huixun Li, Qingguo Liang, Lei Shi, Debing Zhang, Zhen Cai, Sanjun Li, Xinxiang Zhu, Ji Cancer Manag Res Original Research PURPOSE: To investigate the association of age and sex on survival in non-metastatic colorectal cancer (CRC) patients and to identify groups at high risk for poor outcomes. MATERIALS AND METHODS: We performed a retrospective analysis of 5,047 non-metastatic CRC patients from 2008 to 2013. Data regarding age at diagnosis; gender; tumor site; tumor stage; differentiation; lymphatic, neural or vascular invasion; and survival outcomes were collected. Patients were stratified into 10-year age groups (≤35, 36–45, 46–55, 56–65, 66–75, >75) and then further analyzed in three age groups (≤35, 36–75, >75). Disease-free survival (DFS) and overall survival (OS) were evaluated using univariate and multivariate Cox regression models. RESULTS: Of the 5,047 eligible patients, 41.3% were female. The tumor stages were balanced between the genders. In the female patients, the tumor stages were similarly distributed among the different age groups, while younger male patients were diagnosed with more advanced disease (P<0.001 for trend). When stratified into three age groups, young females experienced significantly poorer survival than young males (DFS: hazard ratio [HR]=1.85 [1.04–3.30], OS: HR=2.65 [1.11–6.34]). After adjusting for tumor stage, site, differentiated grade and lymphatic or vascular invasion status, females ≤35 and >75 had shorter DFS than patients between 36 and 75 years old (HR=1.57 [1.03–2.38] and HR=1.51 [1.11–2.05, respectively]), while there was no difference in DFS between females ≤35 and those >75. For male patients, older age was associated with poorer OS after the same adjustment. CONCLUSION: Young female CRC patients (≤35 years old) had the poorest DFS and quite poor OS compared to the other age groups. This emphasizes the need for health care providers to have a heightened awareness and to conduct further research when caring for young female CRC patients. Dove Medical Press 2018-04-04 /pmc/articles/PMC5894745/ /pubmed/29670399 http://dx.doi.org/10.2147/CMAR.S159901 Text en © 2018 Shen et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Shen, Lijun
Mo, Miao
Jia, Leon
Jia, Huixun
Li, Qingguo
Liang, Lei
Shi, Debing
Zhang, Zhen
Cai, Sanjun
Li, Xinxiang
Zhu, Ji
Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title_full Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title_fullStr Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title_full_unstemmed Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title_short Poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in China
title_sort poorer prognosis in young female patients with non-metastatic colorectal cancer: a hospital-based analysis of 5,047 patients in china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894745/
https://www.ncbi.nlm.nih.gov/pubmed/29670399
http://dx.doi.org/10.2147/CMAR.S159901
work_keys_str_mv AT shenlijun poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT momiao poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT jialeon poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT jiahuixun poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT liqingguo poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT lianglei poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT shidebing poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT zhangzhen poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT caisanjun poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT lixinxiang poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina
AT zhuji poorerprognosisinyoungfemalepatientswithnonmetastaticcolorectalcancerahospitalbasedanalysisof5047patientsinchina