Cargando…

Are pilot trials useful for predicting randomisation and attrition rates in definitive studies: A review of publicly funded trials

BACKGROUND/AIMS: External pilot trials are recommended for testing the feasibility of main or confirmatory trials. However, there is little evidence that progress in external pilot trials actually predicts randomisation and attrition rates in the main trial. To assess the use of external pilot trial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cooper, Cindy L, Whitehead, Amy, Pottrill, Edward, Julious, Steven A, Walters, Stephen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894808/ https://www.ncbi.nlm.nih.gov/pubmed/29361833 http://dx.doi.org/10.1177/1740774517752113

Ejemplares similares

Do pilot trials reliably predict recruitment and retention rates for full trial? A review of HTA funded trials
por: Whitehead, Amy, et al.
Publicado: (2015)

Progression criteria in trials with an internal pilot: an audit of publicly funded randomised controlled trials
por: Herbert, Esther, et al.
Publicado: (2019)

Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable
por: Whitehead, Amy L, et al.
Publicado: (2015)

An investigation of the impact of futility analysis in publicly funded trials
por: Sully, Benjamin GO, et al.
Publicado: (2014)

A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies
por: Sully, Ben G O, et al.
Publicado: (2013)

Strategies to reduce attrition in randomised trials
por: Brueton, Valerie, et al.
Publicado: (2011)

Guidance for using pilot studies to inform the design of intervention trials with continuous outcomes
por: Bell, Melanie L, et al.
Publicado: (2018)

The statistical interpretation of pilot trials: should significance thresholds be reconsidered?
por: Lee, Ellen C, et al.
Publicado: (2014)

A study of target effect sizes in randomised controlled trials published in the Health Technology Assessment journal
por: Rothwell, Joanne C., et al.
Publicado: (2018)

Recruitment and retention of participants in randomised controlled trials: a review of trials funded and published by the United Kingdom Health Technology Assessment Programme
por: Walters, Stephen J, et al.
Publicado: (2017)

An audit of sample sizes for pilot and feasibility trials being undertaken in the United Kingdom registered in the United Kingdom Clinical Research Network database
por: Billingham, Sophie AM, et al.
Publicado: (2013)

Investigation of the shortcomings of the consort 2010 statement for the reporting of group sequential randomised controlled trials
por: Dimairo, Munyaradzi, et al.
Publicado: (2015)

NOURISH, Nutritional OUtcomes from a Randomised Investigation of Intradialytic oral nutritional Supplements in patients receiving Haemodialysis: a pilot randomised controlled trial
por: Jackson, Louise, et al.
Publicado: (2015)

Sample size requirements for pilot randomised controlled trials with binary outcomes: a simulation study
por: Teare, Dawn, et al.
Publicado: (2013)

Sample size requirements for pilot randomised controlled trials with continuous outcomes: a simulation study
por: Teare, Marion, et al.
Publicado: (2013)

Clinical and cost effectiveness of computer treatment for aphasia post stroke (Big CACTUS): study protocol for a randomised controlled trial
por: Palmer, Rebecca, et al.
Publicado: (2015)

Nutritional outcomes from a randomised investigation of intradialytic oral nutritional supplements in patients receiving haemodialysis, (NOURISH): a protocol for a pilot randomised controlled trial
por: Jackson, Louise, et al.
Publicado: (2013)

Determining external randomised pilot trial feasibility in preparation for a definitive trial: a web-based survey of corresponding authors of external pilot trial publications
por: Mellor, Katie, et al.
Publicado: (2023)

An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review
por: Stevely, Abigail, et al.
Publicado: (2015)

Statistical analysis of publicly funded cluster randomised controlled trials: a review of the National Institute for Health Research Journals Library
por: Offorha, Bright C., et al.
Publicado: (2022)

Predicting attrition of men with a history of violence from randomised clinical trials
por: Doring, Natalie, et al.
Publicado: (2023)

Trial registration and time to publication in a retrospective cohort of publicly funded randomised controlled trials in New Zealand 1999–2017
por: Jull, Andrew, et al.
Publicado: (2022)

Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study
por: Teare, M Dawn, et al.
Publicado: (2014)

Sample sizes for cluster-randomised trials with continuous outcomes: Accounting for uncertainty in a single intra-cluster correlation estimate
por: Lewis, Jen, et al.
Publicado: (2021)

Is a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial
por: Fuller, Gordon, et al.
Publicado: (2020)

Recruitment to publicly funded trials — Are surgical trials really different?
por: Cook, Jonathan A., et al.
Publicado: (2008)

Use of routinely collected data in a UK cohort of publicly funded randomised clinical trials
por: McKay, Andrew J., et al.
Publicado: (2021)

Learning and confirming in publicly funded antiviral trials
por: Standing, Joseph F, et al.
Publicado: (2023)

Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: the PLEASANT trial
por: Julious, Steven A, et al.
Publicado: (2018)

Despite an improved aerobic endurance, still high attrition rates in initially low-fit recruits—results of a randomised controlled trial
por: Dijksma, I., et al.
Publicado: (2020)

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies
por: McDonald, Alison M, et al.
Publicado: (2006)

Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome
por: Carlton, Erin F., et al.
Publicado: (2021)

A retrospective analysis of conditional power assumptions in clinical trials with continuous or binary endpoints
por: Edwards, Julia M., et al.
Publicado: (2023)

Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial
por: Selvarajah, Dinesh, et al.
Publicado: (2018)

Approaches to multiplicity in publicly funded pragmatic randomised controlled trials: a survey of clinical trials units and a rapid review of published trials
por: Pike, Katie, et al.
Publicado: (2022)

Factors Affecting Recruitment and Attrition in Randomised Controlled Trials of Complementary and Alternative Medicine for Pregnancy-Related Issues
por: Close, Ciara, et al.
Publicado: (2016)

Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials
por: Lees, Jennifer S, et al.
Publicado: (2022)

Factors associated with study attrition in a pilot randomised controlled trial to explore the role of exercise-assisted reduction to stop (EARS) smoking in disadvantaged groups
por: Thompson, T. P., et al.
Publicado: (2016)

Time to publication for publicly funded clinical trials in Australia: an observational study
por: Strand, Linn Beate, et al.
Publicado: (2017)

Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study
por: Amstutz, Alain, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qb7hpoplp7cbi8sji2b5slbkpb