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Use of zebrafish to study Shigella infection

Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella bi...

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Detalles Bibliográficos
Autores principales: Duggan, Gina M., Mostowy, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894947/
https://www.ncbi.nlm.nih.gov/pubmed/29590642
http://dx.doi.org/10.1242/dmm.032151
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author Duggan, Gina M.
Mostowy, Serge
author_facet Duggan, Gina M.
Mostowy, Serge
author_sort Duggan, Gina M.
collection PubMed
description Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo. Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.
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spelling pubmed-58949472018-04-12 Use of zebrafish to study Shigella infection Duggan, Gina M. Mostowy, Serge Dis Model Mech Review Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo. Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans. The Company of Biologists Ltd 2018-02-01 /pmc/articles/PMC5894947/ /pubmed/29590642 http://dx.doi.org/10.1242/dmm.032151 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Duggan, Gina M.
Mostowy, Serge
Use of zebrafish to study Shigella infection
title Use of zebrafish to study Shigella infection
title_full Use of zebrafish to study Shigella infection
title_fullStr Use of zebrafish to study Shigella infection
title_full_unstemmed Use of zebrafish to study Shigella infection
title_short Use of zebrafish to study Shigella infection
title_sort use of zebrafish to study shigella infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894947/
https://www.ncbi.nlm.nih.gov/pubmed/29590642
http://dx.doi.org/10.1242/dmm.032151
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