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The presence of rNTPs decreases the speed of mitochondrial DNA replication

Ribonucleotides (rNMPs) are frequently incorporated during replication or repair by DNA polymerases and failure to remove them leads to instability of nuclear DNA (nDNA). Conversely, rNMPs appear to be relatively well-tolerated in mitochondrial DNA (mtDNA), although the mechanisms behind the toleran...

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Detalles Bibliográficos
Autores principales:	Forslund, Josefin M. E., Pfeiffer, Annika, Stojkovič, Gorazd, Wanrooij, Paulina H., Wanrooij, Sjoerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895052/ https://www.ncbi.nlm.nih.gov/pubmed/29601571 http://dx.doi.org/10.1371/journal.pgen.1007315

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