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A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study

Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the accuracy of thos...

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Autores principales: Yang, Huanhuan, Chen, Guochong, Song, Chunli, Li, Deming, Ma, Qinghua, Chen, Guangliang, Li, Xinli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895391/
https://www.ncbi.nlm.nih.gov/pubmed/29595690
http://dx.doi.org/10.1097/MD.0000000000010272
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author Yang, Huanhuan
Chen, Guochong
Song, Chunli
Li, Deming
Ma, Qinghua
Chen, Guangliang
Li, Xinli
author_facet Yang, Huanhuan
Chen, Guochong
Song, Chunli
Li, Deming
Ma, Qinghua
Chen, Guangliang
Li, Xinli
author_sort Yang, Huanhuan
collection PubMed
description Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the accuracy of those indexes need to be improved. Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored. Area under the receiver operating characteristic curves (AUROC) and Youden index (YI) were calculated to assess the diagnostic value. The AUROC of CI was higher than FLI, HSI, and TyG (CI: 0.897, FLI: 0.873, HSI: 0.855, TyG: 0.793). Therefore, CI might be a better index for the diagnosis of NAFLD. Although there had no statistical significance (P = .123), the AUROC and YI were increased when CI combined with rs2854116 (S1) (AUROC = 0.902, YI = 0.6844). The combination of CI with S1 showed even better diagnostic accuracy than CI, which suggests the potential value of rs2854116 for the diagnosis of NAFLD.
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spelling pubmed-58953912018-04-18 A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study Yang, Huanhuan Chen, Guochong Song, Chunli Li, Deming Ma, Qinghua Chen, Guangliang Li, Xinli Medicine (Baltimore) 4500 Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the accuracy of those indexes need to be improved. Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored. Area under the receiver operating characteristic curves (AUROC) and Youden index (YI) were calculated to assess the diagnostic value. The AUROC of CI was higher than FLI, HSI, and TyG (CI: 0.897, FLI: 0.873, HSI: 0.855, TyG: 0.793). Therefore, CI might be a better index for the diagnosis of NAFLD. Although there had no statistical significance (P = .123), the AUROC and YI were increased when CI combined with rs2854116 (S1) (AUROC = 0.902, YI = 0.6844). The combination of CI with S1 showed even better diagnostic accuracy than CI, which suggests the potential value of rs2854116 for the diagnosis of NAFLD. Wolters Kluwer Health 2018-03-30 /pmc/articles/PMC5895391/ /pubmed/29595690 http://dx.doi.org/10.1097/MD.0000000000010272 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4500
Yang, Huanhuan
Chen, Guochong
Song, Chunli
Li, Deming
Ma, Qinghua
Chen, Guangliang
Li, Xinli
A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title_full A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title_fullStr A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title_full_unstemmed A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title_short A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study
title_sort novel index including snps for the screening of nonalcoholic fatty liver disease among elder chinese: a population-based study
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895391/
https://www.ncbi.nlm.nih.gov/pubmed/29595690
http://dx.doi.org/10.1097/MD.0000000000010272
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