Cargando…

Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department

Elderly people are more susceptible to sepsis and experience more comorbidities and complications than young adults. Serum lactate is a useful biomarker to predict mortality in patients with sepsis. Lactate production is affected by the severity of sepsis, organ dysfunction, and adrenergic stimulati...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Hsien-Hung, Chen, Fu-Cheng, Change, Meng-Wei, Kung, Chia-Te, Cheng, Chi-Yung, Tsai, Tsung-Cheng, Hsiao, Sheng-Yuan, Su, Chih-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895436/
https://www.ncbi.nlm.nih.gov/pubmed/29595662
http://dx.doi.org/10.1097/MD.0000000000010209
_version_ 1783313662015963136
author Cheng, Hsien-Hung
Chen, Fu-Cheng
Change, Meng-Wei
Kung, Chia-Te
Cheng, Chi-Yung
Tsai, Tsung-Cheng
Hsiao, Sheng-Yuan
Su, Chih-Min
author_facet Cheng, Hsien-Hung
Chen, Fu-Cheng
Change, Meng-Wei
Kung, Chia-Te
Cheng, Chi-Yung
Tsai, Tsung-Cheng
Hsiao, Sheng-Yuan
Su, Chih-Min
author_sort Cheng, Hsien-Hung
collection PubMed
description Elderly people are more susceptible to sepsis and experience more comorbidities and complications than young adults. Serum lactate is a useful biomarker to predict mortality in patients with sepsis. Lactate production is affected by the severity of sepsis, organ dysfunction, and adrenergic stimulation. Whether the predictive ability of serum lactate will be different between non-elderly and elderly patients is unknown. A retrospective cohort study was conducted to compare the prognostic value of hyperlactatemia in predicting the mortality between elderly (≥65 years) and non-elderly (<65 years) patients with sepsis. This is a single-center retrospective observational cohort study conducted from January 2007 to December 2013 in southern Taiwan. All patients with sepsis, who used antibiotics, with blood culture collected, and with available serum lactate levels in the emergency department, were included in the analysis. We evaluated the difference in serum lactate level between the elderly and non-elderly septic patients by using multiple regression models. A total of 7087 patients were enrolled in the study. Elderly and non-elderly patients accounted for 62.3% (4414) and 40.2% (2673) of all patients, respectively. Statistically significant difference of serum lactate levels was not observed between elderly and non-elderly survivors (2.9 vs 3.0 mmol/L; P = .57); however, elderly patients had lower lactate levels than those within the 28-day in-hospital mortality (5.5 vs 6.6 mmol/L, P < .01). Multiple logistic regression revealed higher adjusted mortality risk in elderly and non-elderly patients with lactate levels of ≥4.0 mmol/L (odds ratio [OR], 4.98 and 5.82; P < .01, respectively), and lactate level between 2 and 4 mmol/L (OR, 1.57 and 1.99; P < .01, respectively) compared to that in the reference group with lactate levels of <2.0 mmol/L in each group. In receiver operating characteristic curve analysis, sensitivity rates for predicting mortality were 0.80 and 0.77 for non-elderly and elderly patients, respectively, by using serum lactate levels higher than 2.0 mmol/L. Septic elderly non-survivors had 1 mmol/L lower serum lactate level than those of the non-elderly non-survivors. Lactate >2 mmol/L still could provide enough sensitivity in predicting sepsis mortality in elder patients.
format Online
Article
Text
id pubmed-5895436
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-58954362018-04-18 Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department Cheng, Hsien-Hung Chen, Fu-Cheng Change, Meng-Wei Kung, Chia-Te Cheng, Chi-Yung Tsai, Tsung-Cheng Hsiao, Sheng-Yuan Su, Chih-Min Medicine (Baltimore) 3900 Elderly people are more susceptible to sepsis and experience more comorbidities and complications than young adults. Serum lactate is a useful biomarker to predict mortality in patients with sepsis. Lactate production is affected by the severity of sepsis, organ dysfunction, and adrenergic stimulation. Whether the predictive ability of serum lactate will be different between non-elderly and elderly patients is unknown. A retrospective cohort study was conducted to compare the prognostic value of hyperlactatemia in predicting the mortality between elderly (≥65 years) and non-elderly (<65 years) patients with sepsis. This is a single-center retrospective observational cohort study conducted from January 2007 to December 2013 in southern Taiwan. All patients with sepsis, who used antibiotics, with blood culture collected, and with available serum lactate levels in the emergency department, were included in the analysis. We evaluated the difference in serum lactate level between the elderly and non-elderly septic patients by using multiple regression models. A total of 7087 patients were enrolled in the study. Elderly and non-elderly patients accounted for 62.3% (4414) and 40.2% (2673) of all patients, respectively. Statistically significant difference of serum lactate levels was not observed between elderly and non-elderly survivors (2.9 vs 3.0 mmol/L; P = .57); however, elderly patients had lower lactate levels than those within the 28-day in-hospital mortality (5.5 vs 6.6 mmol/L, P < .01). Multiple logistic regression revealed higher adjusted mortality risk in elderly and non-elderly patients with lactate levels of ≥4.0 mmol/L (odds ratio [OR], 4.98 and 5.82; P < .01, respectively), and lactate level between 2 and 4 mmol/L (OR, 1.57 and 1.99; P < .01, respectively) compared to that in the reference group with lactate levels of <2.0 mmol/L in each group. In receiver operating characteristic curve analysis, sensitivity rates for predicting mortality were 0.80 and 0.77 for non-elderly and elderly patients, respectively, by using serum lactate levels higher than 2.0 mmol/L. Septic elderly non-survivors had 1 mmol/L lower serum lactate level than those of the non-elderly non-survivors. Lactate >2 mmol/L still could provide enough sensitivity in predicting sepsis mortality in elder patients. Wolters Kluwer Health 2018-03-30 /pmc/articles/PMC5895436/ /pubmed/29595662 http://dx.doi.org/10.1097/MD.0000000000010209 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3900
Cheng, Hsien-Hung
Chen, Fu-Cheng
Change, Meng-Wei
Kung, Chia-Te
Cheng, Chi-Yung
Tsai, Tsung-Cheng
Hsiao, Sheng-Yuan
Su, Chih-Min
Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title_full Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title_fullStr Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title_full_unstemmed Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title_short Difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
title_sort difference between elderly and non-elderly patients in using serum lactate level to predict mortality caused by sepsis in the emergency department
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895436/
https://www.ncbi.nlm.nih.gov/pubmed/29595662
http://dx.doi.org/10.1097/MD.0000000000010209
work_keys_str_mv AT chenghsienhung differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT chenfucheng differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT changemengwei differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT kungchiate differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT chengchiyung differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT tsaitsungcheng differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT hsiaoshengyuan differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment
AT suchihmin differencebetweenelderlyandnonelderlypatientsinusingserumlactateleveltopredictmortalitycausedbysepsisintheemergencydepartment