Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

It is well documented that hypoxia activates the hypoxia-inducible factor 1-alpha (HIF1α)/vascular endothelial growth factor A (VEGFA) axis to promote angiogenesis in breast cancer. However, it is unclear how this axis is negatively regulated. In this study, we demonstrated that miR-153 directly inh...

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Detalles Bibliográficos
Autores principales: Liang, Huichun, Xiao, Ji, Zhou, Zhongmei, Wu, Jiao, Ge, Fei, Li, Zongcheng, Zhang, Hailin, Sun, Jian, Li, Fubing, Liu, Rong, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895606/
https://www.ncbi.nlm.nih.gov/pubmed/29367761
http://dx.doi.org/10.1038/s41388-017-0089-8

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