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Intrinsically-disordered N-termini in human parechovirus 1 capsid proteins bind encapsidated RNA

Human parechoviruses (HPeV) are picornaviruses with a highly-ordered RNA genome contained within icosahedrally-symmetric capsids. Ordered RNA structures have recently been shown to interact with capsid proteins VP1 and VP3 and facilitate virus assembly in HPeV1. Using an assay that combines reversib...

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Detalles Bibliográficos
Autores principales: Shakeel, Shabih, Evans, James D., Hazelbaker, Mark, Kao, C. Cheng, Vaughan, Robert C., Butcher, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895611/
https://www.ncbi.nlm.nih.gov/pubmed/29643409
http://dx.doi.org/10.1038/s41598-018-23552-7