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Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were...

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Detalles Bibliográficos
Autores principales:	Richard, Matthias, Gutiérrez, Ana Victoria, Viljoen, Albertus J., Ghigo, Eric, Blaise, Mickael, Kremer, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895659/ https://www.ncbi.nlm.nih.gov/pubmed/29675007 http://dx.doi.org/10.3389/fmicb.2018.00649

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