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SALM/Lrfn Family Synaptic Adhesion Molecules
Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibron...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895706/ https://www.ncbi.nlm.nih.gov/pubmed/29674953 http://dx.doi.org/10.3389/fnmol.2018.00105 |
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author | Lie, Eunkyung Li, Yan Kim, Ryunhee Kim, Eunjoon |
author_facet | Lie, Eunkyung Li, Yan Kim, Ryunhee Kim, Eunjoon |
author_sort | Lie, Eunkyung |
collection | PubMed |
description | Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein. While studies over the last decade have steadily explored the basic properties and synaptic and neuronal functions of SALMs, a number of recent studies have provided novel insights into molecular, structural, functional and clinical aspects of SALMs. Here we summarize these findings and discuss how SALMs act in concert with other synaptic proteins to regulate synapse development and function. |
format | Online Article Text |
id | pubmed-5895706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58957062018-04-19 SALM/Lrfn Family Synaptic Adhesion Molecules Lie, Eunkyung Li, Yan Kim, Ryunhee Kim, Eunjoon Front Mol Neurosci Neuroscience Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein. While studies over the last decade have steadily explored the basic properties and synaptic and neuronal functions of SALMs, a number of recent studies have provided novel insights into molecular, structural, functional and clinical aspects of SALMs. Here we summarize these findings and discuss how SALMs act in concert with other synaptic proteins to regulate synapse development and function. Frontiers Media S.A. 2018-04-05 /pmc/articles/PMC5895706/ /pubmed/29674953 http://dx.doi.org/10.3389/fnmol.2018.00105 Text en Copyright © 2018 Lie, Li, Kim and Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lie, Eunkyung Li, Yan Kim, Ryunhee Kim, Eunjoon SALM/Lrfn Family Synaptic Adhesion Molecules |
title | SALM/Lrfn Family Synaptic Adhesion Molecules |
title_full | SALM/Lrfn Family Synaptic Adhesion Molecules |
title_fullStr | SALM/Lrfn Family Synaptic Adhesion Molecules |
title_full_unstemmed | SALM/Lrfn Family Synaptic Adhesion Molecules |
title_short | SALM/Lrfn Family Synaptic Adhesion Molecules |
title_sort | salm/lrfn family synaptic adhesion molecules |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895706/ https://www.ncbi.nlm.nih.gov/pubmed/29674953 http://dx.doi.org/10.3389/fnmol.2018.00105 |
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