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Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2
Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control of synapse maintenance and plasticity. Hippoca...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895709/ https://www.ncbi.nlm.nih.gov/pubmed/29674952 http://dx.doi.org/10.3389/fnmol.2018.00103 |
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author | De Bruyckere, Elodie Simon, Ruth Nestel, Sigrun Heimrich, Bernd Kätzel, Dennis Egorov, Alexei V. Liu, Pentao Jenkins, Nancy A. Copeland, Neal G. Schwegler, Herbert Draguhn, Andreas Britsch, Stefan |
author_facet | De Bruyckere, Elodie Simon, Ruth Nestel, Sigrun Heimrich, Bernd Kätzel, Dennis Egorov, Alexei V. Liu, Pentao Jenkins, Nancy A. Copeland, Neal G. Schwegler, Herbert Draguhn, Andreas Britsch, Stefan |
author_sort | De Bruyckere, Elodie |
collection | PubMed |
description | Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control of synapse maintenance and plasticity. Hippocampal mossy fiber (MF) synapses connect dentate granule cells to CA3 pyramidal neurons and are important for spatial memory formation and consolidation. The transcription factor Bcl11b/Ctip2 is expressed in dentate granule cells and required for postnatal hippocampal development. Ablation of Bcl11b/Ctip2 in the adult hippocampus results in impaired adult neurogenesis and spatial memory. The molecular mechanisms underlying the behavioral impairment remained unclear. Here we show that selective deletion of Bcl11b/Ctip2 in the adult mouse hippocampus leads to a rapid loss of excitatory synapses in CA3 as well as reduced ultrastructural complexity of remaining mossy fiber boutons (MFBs). Moreover, a dramatic decline of long-term potentiation (LTP) of the dentate gyrus-CA3 (DG-CA3) projection is caused by adult loss of Bcl11b/Ctip2. Differential transcriptomics revealed the deregulation of genes associated with synaptic transmission in mutants. Together, our data suggest Bcl11b/Ctip2 to regulate maintenance and function of MF synapses in the adult hippocampus. |
format | Online Article Text |
id | pubmed-5895709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58957092018-04-19 Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 De Bruyckere, Elodie Simon, Ruth Nestel, Sigrun Heimrich, Bernd Kätzel, Dennis Egorov, Alexei V. Liu, Pentao Jenkins, Nancy A. Copeland, Neal G. Schwegler, Herbert Draguhn, Andreas Britsch, Stefan Front Mol Neurosci Neuroscience Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control of synapse maintenance and plasticity. Hippocampal mossy fiber (MF) synapses connect dentate granule cells to CA3 pyramidal neurons and are important for spatial memory formation and consolidation. The transcription factor Bcl11b/Ctip2 is expressed in dentate granule cells and required for postnatal hippocampal development. Ablation of Bcl11b/Ctip2 in the adult hippocampus results in impaired adult neurogenesis and spatial memory. The molecular mechanisms underlying the behavioral impairment remained unclear. Here we show that selective deletion of Bcl11b/Ctip2 in the adult mouse hippocampus leads to a rapid loss of excitatory synapses in CA3 as well as reduced ultrastructural complexity of remaining mossy fiber boutons (MFBs). Moreover, a dramatic decline of long-term potentiation (LTP) of the dentate gyrus-CA3 (DG-CA3) projection is caused by adult loss of Bcl11b/Ctip2. Differential transcriptomics revealed the deregulation of genes associated with synaptic transmission in mutants. Together, our data suggest Bcl11b/Ctip2 to regulate maintenance and function of MF synapses in the adult hippocampus. Frontiers Media S.A. 2018-04-05 /pmc/articles/PMC5895709/ /pubmed/29674952 http://dx.doi.org/10.3389/fnmol.2018.00103 Text en Copyright © 2018 De Bruyckere, Simon, Nestel, Heimrich, Kätzel, Egorov, Liu, Jenkins, Copeland, Schwegler, Draguhn and Britsch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience De Bruyckere, Elodie Simon, Ruth Nestel, Sigrun Heimrich, Bernd Kätzel, Dennis Egorov, Alexei V. Liu, Pentao Jenkins, Nancy A. Copeland, Neal G. Schwegler, Herbert Draguhn, Andreas Britsch, Stefan Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title | Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title_full | Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title_fullStr | Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title_full_unstemmed | Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title_short | Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2 |
title_sort | stability and function of hippocampal mossy fiber synapses depend on bcl11b/ctip2 |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895709/ https://www.ncbi.nlm.nih.gov/pubmed/29674952 http://dx.doi.org/10.3389/fnmol.2018.00103 |
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