Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

The development of three-dimensional culture methods has allowed for the study of developing cortical morphology in human cells. This provides a new tool to study the neurodevelopmental consequences of disease-associated mutations. Here, we study the effects of isogenic DISC1 mutation in cerebral or...

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Detalles Bibliográficos
Autores principales: Srikanth, Priya, Lagomarsino, Valentina N., Muratore, Christina R., Ryu, Steven C., He, Amy, Taylor, Walter M., Zhou, Constance, Arellano, Marlise, Young-Pearse, Tracy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895714/
https://www.ncbi.nlm.nih.gov/pubmed/29643329
http://dx.doi.org/10.1038/s41398-018-0122-x

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